This substantial stage expression most likely accounts for the presence of torsinA staining in the nucleus of transfected neurons, as the endogenous protein is exclusively cytoplasmic
Effect of Cre-mediated deletion of the Dyt1 gene on vulnerability of dopaminergic neurons to MPTP. rAAV-Cre was administered unilaterally to Dyt1-loxP mice and C57/B6 manage animals. One month following rAAV…