Inhibition of VEGF synthesis and function by antisense oligonucleotide and by suramin, respectively arrested the BMP-seven induced alkaline phosphatase activity and mineralized bone nodule formation [35]
It is effectively known that VEGF is actively dependable for hypertrophic cartilage neovascularization via a paracrine release by chondrocytes , and partners hypertrophic cartilage transforming, ossification and angiogenesis in the…