Desert Hedgehog/Dhh Antibody (RM0087-7C8) Summary
Mouse recombinant dhh C-terminal fragment
This was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with mouse recombinant protein of dhh C-terminal fragment.
IgG2
Monoclonal
Rat
DHH
Protein G purified
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Applications/Dilutions
- Western Blot 1:500-1:1000
This antibody detects mouse dhh C-terminal polypeptides, but not Nterminal one in Western blotting.
Reactivity Notes
Mouse.
Packaging, Storage & Formulations
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
A 0.2 um filtered solution in PBS
No Preservative
LYOPH
Protein G purified
Reconstitute with 0.2 ml sterilized PBS to a final concentration of 0.5 mg/ml.
Alternate Names for Desert Hedgehog/Dhh Antibody (RM0087-7C8)
- desert hedgehog (Drosophila) homolog
- desert hedgehog homolog
- desert hedgehog protein
- Desert Hedgehog
- DHH
- HHG-3MGC35145
Background
This gene encodes a member of the Hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N terminal portion is soluble and contains the signalling activity while the C terminal portion is involved in precursor processing. More importantly, the C terminal product covalently attaches a cholesterol moiety to the N terminal product, restricting the N terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.