Product Name :
BPN14770
Description:
BPN14770 is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively.
CAS:
1606974-33-7
Molecular Weight:
405.80
Formula:
C21H15ClF3NO2
Chemical Name:
2-(4-[2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl]methylphenyl)acetic acid
Smiles :
OC(=O)CC1C=CC(CC2=CC(=NC(=C2)C(F)(F)F)C2C=C(Cl)C=CC=2)=CC=1
InChiKey:
LTSUMTMGJHPGFX-UHFFFAOYSA-N
InChi :
InChI=1S/C21H15ClF3NO2/c22-17-3-1-2-16(12-17)18-9-15(10-19(26-18)21(23,24)25)8-13-4-6-14(7-5-13)11-20(27)28/h1-7,9-10,12H,8,11H2,(H,27,28)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Ticagrelor In stock
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
BPN14770 is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.Primidone Membrane Transporter/Ion Channel 8 nM and 7.PMID:32310442 4 nM for PDE4D7 and PDE4D3, respectively.|Product information|CAS Number: 1606974-33-7|Molecular Weight: 405.80|Formula: C21H15ClF3NO2|Chemical Name: 2-(4-[2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl]methylphenyl)acetic acid|Smiles: OC(=O)CC1C=CC(CC2=CC(=NC(=C2)C(F)(F)F)C2C=C(Cl)C=CC=2)=CC=1|InChiKey: LTSUMTMGJHPGFX-UHFFFAOYSA-N|InChi: InChI=1S/C21H15ClF3NO2/c22-17-3-1-2-16(12-17)18-9-15(10-19(26-18)21(23,24)25)8-13-4-6-14(7-5-13)11-20(27)28/h1-7,9-10,12H,8,11H2,(H,27,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 260 mg/mL (640.71 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|BPN14770 increases brain cAMP, increases phosphorylation of CREB and increases production of brain-derived neurotrophic factor (BDNF) in hippocampus. BPN14770 (0.1-30 mg/kg; p.o.; 24 hours) provides cognitive benefit in the mouse novel object recognition (NOR) at doses above 0.3 mg/kg.|Products are for research use only. Not for human use.|