Product Name :
USP7-IN-5
Description:
USP7-IN-5 is a potent ubiquitin specific protease 7 (USP7) inhibitor extracted from patent WO2017212012A1, example 40, has an IC50 of 49.9 nM.
CAS:
2166599-74-0
Molecular Weight:
641.76
Formula:
C36H43N5O6
Chemical Name:
tert-butyl (3R,4R)-4-(4-hydroxy-4-[7-(4-methoxyphenyl)-4-oxo-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-3-yl]methylpiperidine-1-carbonyl)-3-phenylpiperidine-1-carboxylate
Smiles :
CC(C)(C)OC(=O)N1C[C@H]([C@@H](CC1)C(=O)N1CCC(O)(CN2C=NC3=C(C=CN3C3C=CC(=CC=3)OC)C2=O)CC1)C1C=CC=CC=1
InChiKey:
QKYAFWNZSJXZFS-DGPALRBDSA-N
InChi :
InChI=1S/C36H43N5O6/c1-35(2,3)47-34(44)39-18-14-28(30(22-39)25-8-6-5-7-9-25)32(42)38-20-16-36(45,17-21-38)23-40-24-37-31-29(33(40)43)15-19-41(31)26-10-12-27(46-4)13-11-26/h5-13,15,19,24,28,30,45H,14,16-18,20-23H2,1-4H3/t28-,30+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
USP7-IN-5 is a potent ubiquitin specific protease 7 (USP7) inhibitor extracted from patent WO2017212012A1, example 40, has an IC50 of 49.Semaglutide web 9 nM.|Product information|CAS Number: 2166599-74-0|Molecular Weight: 641.76|Formula: C36H43N5O6|Chemical Name: tert-butyl (3R,4R)-4-(4-hydroxy-4-[7-(4-methoxyphenyl)-4-oxo-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-3-yl]methylpiperidine-1-carbonyl)-3-phenylpiperidine-1-carboxylate|Smiles: CC(C)(C)OC(=O)N1C[C@H]([C@@H](CC1)C(=O)N1CCC(O)(CN2C=NC3=C(C=CN3C3C=CC(=CC=3)OC)C2=O)CC1)C1C=CC=CC=1|InChiKey: QKYAFWNZSJXZFS-DGPALRBDSA-N|InChi: InChI=1S/C36H43N5O6/c1-35(2,3)47-34(44)39-18-14-28(30(22-39)25-8-6-5-7-9-25)32(42)38-20-16-36(45,17-21-38)23-40-24-37-31-29(33(40)43)15-19-41(31)26-10-12-27(46-4)13-11-26/h5-13,15,19,24,28,30,45H,14,16-18,20-23H2,1-4H3/t28-,30+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Zilucoplan web |Shelf Life: ≥12 months if stored properly.PMID:33125298 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|USP7-IN-5 (example 40) shows cytotoxicity to MM1S cells, with an IC50 31.5 nM.|References:|András Kotschy, et al. New piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them. WO2017212012A1.Products are for research use only. Not for human use.|