Product Name :
Herbacetin
Description:
Herbacetin is a natural flavonoid from flaxseed, exerts various pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects. Herbacetin is an Ornithine decarboxylase (ODC) allosteric inhibitor, directly binds to Asp44, Asp243, and Glu384 on ODC. Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis.
CAS:
527-95-7
Molecular Weight:
302.24
Formula:
C15H10O7
Chemical Name:
3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
Smiles :
OC1C=C(O)C(O)=C2OC(C3C=CC(O)=CC=3)=C(O)C(=O)C=12
InChiKey:
ZDOTZEDNGNPOEW-UHFFFAOYSA-N
InChi :
InChI=1S/C15H10O7/c16-7-3-1-6(2-4-7)14-13(21)12(20)10-8(17)5-9(18)11(19)15(10)22-14/h1-5,16-19,21H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Spironolactone} MedChemExpress|{Spironolactone} Autophagy|{Spironolactone} Protocol|{Spironolactone} In stock|{Spironolactone} supplier|{Spironolactone} Autophagy}
Additional information:
Herbacetin is a natural flavonoid from flaxseed, exerts various pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects.{{Mangiferin} web|{Mangiferin} Apoptosis|{Mangiferin} Technical Information|{Mangiferin} Description|{Mangiferin} manufacturer|{Mangiferin} Epigenetics} Herbacetin is an Ornithine decarboxylase (ODC) allosteric inhibitor, directly binds to Asp44, Asp243, and Glu384 on ODC.PMID:33118142 Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis.|Product information|CAS Number: 527-95-7|Molecular Weight: 302.24|Formula: C15H10O7|Chemical Name: 3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one|Smiles: OC1C=C(O)C(O)=C2OC(C3C=CC(O)=CC=3)=C(O)C(=O)C=12|InChiKey: ZDOTZEDNGNPOEW-UHFFFAOYSA-N|InChi: InChI=1S/C15H10O7/c16-7-3-1-6(2-4-7)14-13(21)12(20)10-8(17)5-9(18)11(19)15(10)22-14/h1-5,16-19,21H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (330.86 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Herbacetin (orally administration; 20mg/kg) significantly reduces the body weight, plasma glucose, plasma insulin, and HOMA-IR activity in obesity associated insulin resistant mice (OIR). (Herbacetin dissolves in 0.5% DMSO). Herbacetin (intraperitoneal injection; 0.4, 2, 10 or 20 mg/kg; B.W.) decreases the number and size of polyps in APCMin+ mice with no overt toxicity.|Products are for research use only. Not for human use.|