Product Name :
JUN76288
Description:
JUN76288, also known WEE1-IN-3, is a potent WEE1 kinase inhibitors useful in treatment of cancer and other proliferative diseases.
CAS:
2272976-28-8
Molecular Weight:
497.59
Formula:
C28H31N7O2
Chemical Name:
6-[(2′, 3′-Dihydro-2′-methylspiro[cyclopropane-1, 4′(1’H)-isoquinolin]-7′-yl)amino]-1, 2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)-3H-pyrazolo[3, 4-d]pyrimidin-3-one
Smiles :
CC(C)(O)C1=CC=CC(=N1)N1C2=NC(NC3=CC4CN(C)CC5(CC5)C=4C=C3)=NC=C2C(=O)N1CC=C
InChiKey:
JSZFIXAMFNNRKS-UHFFFAOYSA-N
InChi :
InChI=1S/C28H31N7O2/c1-5-13-34-25(36)20-15-29-26(32-24(20)35(34)23-8-6-7-22(31-23)27(2,3)37)30-19-9-10-21-18(14-19)16-33(4)17-28(21)11-12-28/h5-10,14-15,37H,1,11-13,16-17H2,2-4H3,(H,29,30,32)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Bortezomib} MedChemExpress|{Bortezomib} Autophagy|{Bortezomib} Protocol|{Bortezomib} Data Sheet|{Bortezomib} manufacturer|{Bortezomib} Autophagy}
Shelf Life:
≥360 days if stored properly.{{Tiamulin} MedChemExpress|{Tiamulin} Anti-infection|{Tiamulin} Epigenetics|{Tiamulin} Biological Activity|{Tiamulin} In stock|{Tiamulin} custom synthesis}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
JUN76288, also known WEE1-IN-3, is a potent WEE1 kinase inhibitors useful in treatment of cancer and other proliferative diseases.PMID:23849184 |Product information|CAS Number: 2272976-28-8|Molecular Weight: 497.59|Formula: C28H31N7O2|Synonym:|WEE1-IN-3|Chemical Name: 6-[(2′, 3′-Dihydro-2′-methylspiro[cyclopropane-1, 4′(1’H)-isoquinolin]-7′-yl)amino]-1, 2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)-3H-pyrazolo[3, 4-d]pyrimidin-3-one|Smiles: CC(C)(O)C1=CC=CC(=N1)N1C2=NC(NC3=CC4CN(C)CC5(CC5)C=4C=C3)=NC=C2C(=O)N1CC=C|InChiKey: JSZFIXAMFNNRKS-UHFFFAOYSA-N|InChi: InChI=1S/C28H31N7O2/c1-5-13-34-25(36)20-15-29-26(32-24(20)35(34)23-8-6-7-22(31-23)27(2,3)37)30-19-9-10-21-18(14-19)16-33(4)17-28(21)11-12-28/h5-10,14-15,37H,1,11-13,16-17H2,2-4H3,(H,29,30,32)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|JUN76288 inhibits cancer cell growth with IC50 values of 100-1000 nM and References:|Peter Qinhua HUANG, et al. 1, 2 – dihydro- 3h- pyrazolo [3, 4 – d] pyrimidin -3 – one analogs. WO2019028008A1.Products are for research use only. Not for human use.|