Product Name :
AVN-944
Description:
AVN-944 (VX-944) is an orally available, synthetic small molecule with potential antineoplastic activity. AVN944 inhibits inosine monosphosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanosine triphosphate (GTP), a purine molecule required for DNA and RNA synthesis. Inhibition of IMPDH deprives cancer cells of GTP, resulting in disruption of DNA and RNA synthesis, inhibition of cell proliferation, and the induction of apoptosis. AVN944 appears to have a selective effect on cancer cells in that deprivation of GTP in normal cells results in a temporary slowing of cell growth only. IMPDH is overexpressed in some cancer cells, particularly in hematological malignancies.
CAS:
297730-17-7
Molecular Weight:
477.51
Formula:
C25H27N5O5
Chemical Name:
(2R)-1-cyanobutan-2-yl N-[(1S)-1-[3-({[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoyl}amino)phenyl]ethyl]carbamate
Smiles :
C[C@H](NC(=O)O[C@@H](CC#N)CC)C1=CC(=CC=C1)NC(=O)NC1=CC(OC)=C(C=C1)C1=CN=CO1
InChiKey:
GYCPCOJTCINIFZ-OXJNMPFZSA-N
InChi :
InChI=1S/C25H27N5O5/c1-4-20(10-11-26)35-25(32)28-16(2)17-6-5-7-18(12-17)29-24(31)30-19-8-9-21(22(13-19)33-3)23-14-27-15-34-23/h5-9,12-16,20H,4,10H2,1-3H3,(H,28,32)(H2,29,30,31)/t16-,20+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Masofaniten} medchemexpress|{Masofaniten} Inhibitor|{Masofaniten} Activator|{Masofaniten} Technical Information|{Masofaniten} Description|{Masofaniten} manufacturer}
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AVN-944 (VX-944) is an orally available, synthetic small molecule with potential antineoplastic activity. AVN944 inhibits inosine monosphosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanosine triphosphate (GTP), a purine molecule required for DNA and RNA synthesis. Inhibition of IMPDH deprives cancer cells of GTP, resulting in disruption of DNA and RNA synthesis, inhibition of cell proliferation, and the induction of apoptosis.{{AK-7} MedChemExpress|{AK-7} Cell Cycle/DNA Damage|{AK-7} Technical Information|{AK-7} Description|{AK-7} supplier|{AK-7} Epigenetic Reader Domain} AVN944 appears to have a selective effect on cancer cells in that deprivation of GTP in normal cells results in a temporary slowing of cell growth only.PMID:23376608 IMPDH is overexpressed in some cancer cells, particularly in hematological malignancies.|Product information|CAS Number: 297730-17-7|Molecular Weight: 477.51|Formula: C25H27N5O5|Chemical Name: (2R)-1-cyanobutan-2-yl N-[(1S)-1-[3-({[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoyl}amino)phenyl]ethyl]carbamate|Smiles: C[C@H](NC(=O)O[C@@H](CC#N)CC)C1=CC(=CC=C1)NC(=O)NC1=CC(OC)=C(C=C1)C1=CN=CO1|InChiKey: GYCPCOJTCINIFZ-OXJNMPFZSA-N|InChi: InChI=1S/C25H27N5O5/c1-4-20(10-11-26)35-25(32)28-16(2)17-6-5-7-18(12-17)29-24(31)30-19-8-9-21(22(13-19)33-3)23-14-27-15-34-23/h5-9,12-16,20H,4,10H2,1-3H3,(H,28,32)(H2,29,30,31)/t16-,20+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|