Product Name :
WAY-600
Description:
WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM.
CAS:
1062159-35-6
Molecular Weight:
494.59
Formula:
C28H30N8O
Chemical Name:
4-(6-(1H-indol-5-yl)-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3, 4-d]pyrimidin-4-yl)morpholine
Smiles :
C(C1=CN=CC=C1)N1CCC(CC1)N1N=CC2C1=NC(=NC=2N1CCOCC1)C1C=C2C=CNC2=CC=1
InChiKey:
FPEIJQLXFHKLJV-UHFFFAOYSA-N
InChi :
InChI=1S/C28H30N8O/c1-2-20(17-29-8-1)19-34-10-6-23(7-11-34)36-28-24(18-31-36)27(35-12-14-37-15-13-35)32-26(33-28)22-3-4-25-21(16-22)5-9-30-25/h1-5,8-9,16-18,23,30H,6-7,10-15,19H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.{{CITCO} MedChemExpress|{CITCO} Apoptosis|{CITCO} Immunology/Inflammation|{CITCO} Biological Activity|{CITCO} In Vitro|{CITCO} manufacturer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM.|Product information|CAS Number: 1062159-35-6|Molecular Weight: 494.59|Formula: C28H30N8O|Chemical Name: 4-(6-(1H-indol-5-yl)-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3, 4-d]pyrimidin-4-yl)morpholine|Smiles: C(C1=CN=CC=C1)N1CCC(CC1)N1N=CC2C1=NC(=NC=2N1CCOCC1)C1C=C2C=CNC2=CC=1|InChiKey: FPEIJQLXFHKLJV-UHFFFAOYSA-N|InChi: InChI=1S/C28H30N8O/c1-2-20(17-29-8-1)19-34-10-6-23(7-11-34)36-28-24(18-31-36)27(35-12-14-37-15-13-35)32-26(33-28)22-3-4-25-21(16-22)5-9-30-25/h1-5,8-9,16-18,23,30H,6-7,10-15,19H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO, not in water|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Phenformin} site|{Phenformin} Epigenetics|{Phenformin} TGF-beta/Smad|{Phenformin} Biological Activity|{Phenformin} Purity|{Phenformin} manufacturer} |Shelf Life: ≥12 months if stored properly.PMID:23443926 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|WAY-600 exhibits a concentration-dependent and time-dependent inhibition of f HepG2 and Huh-7 cells viability. Following WAY-600 (1-1000 nM) treatment, the number of HepG2 cell colonies is dramatically decreased. Meanwhile, BrdU incorporation in HepG2 cells is also inhibited with WAY-600 treatment. WAY-600 dose-dependently increases the activity of caspase-3 and caspase-9 in HepG2 cells. WAY-600 disrupts assemble of mTORC1 (mTOR-Raptor association) and mTORC2 (mTOR-Rictor association). Activation of mTORC1 (indicated by p-S6K1 and p-4E-BP1) and mTORC2 is almost blocked by WAY-600 (100 nM)|In Vivo:|Administration of WAY-600 (10 mg/kg, daily) inhibits HepG2 tumor growth in nude mice. Daily HepG2 tumor growth of WAY-600-administrated mice is significantly lower than that of vehicle control mice. Importantly, the in vivo anti-cancer activity by WAY-600 is further potentiated with the co-administration of MEK-162 (2.5 mg/kg, p.o. daily)[|Products are for research use only. Not for human use.|