Product Name :
RTI-13951-33
Description:
RTI-13951-33 is a potent, selective, and brain-penetrant GPR88 agonist, with an EC50 of 25 nM in GPR88 cAMP functional assay. RTI-13951-33 reduces alcohol reinforcement and intake behaviors in rats.
CAS:
2244884-08-8
Molecular Weight:
459.58
Formula:
C28H33N3O3
Chemical Name:
(1R,2R)-N-[(2R,3R)-2-amino-3-methoxybutyl]-N-[4′-(methoxymethyl)-[1,1′-biphenyl]-4-yl]-2-(pyridin-2-yl)cyclopropane-1-carboxamide
Smiles :
C[C@@H](OC)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1C1=CC=CC=N1)C1C=CC(=CC=1)C1C=CC(COC)=CC=1
InChiKey:
XCHHIKJEGXHKLQ-UJTWYAIMSA-N
InChi :
InChI=1S/C28H33N3O3/c1-19(34-3)26(29)17-31(28(32)25-16-24(25)27-6-4-5-15-30-27)23-13-11-22(12-14-23)21-9-7-20(8-10-21)18-33-2/h4-15,19,24-26H,16-18,29H2,1-3H3/t19-,24-,25-,26-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
RTI-13951-33 is a potent, selective, and brain-penetrant GPR88 agonist, with an EC50 of 25 nM in GPR88 cAMP functional assay. RTI-13951-33 reduces alcohol reinforcement and intake behaviors in rats.|Product information|CAS Number: 2244884-08-8|Molecular Weight: 459.58|Formula: C28H33N3O3|Chemical Name: (1R,2R)-N-[(2R,3R)-2-amino-3-methoxybutyl]-N-[4′-(methoxymethyl)-[1,1′-biphenyl]-4-yl]-2-(pyridin-2-yl)cyclopropane-1-carboxamide|Smiles: C[C@@H](OC)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1C1=CC=CC=N1)C1C=CC(=CC=1)C1C=CC(COC)=CC=1|InChiKey: XCHHIKJEGXHKLQ-UJTWYAIMSA-N|InChi: InChI=1S/C28H33N3O3/c1-19(34-3)26(29)17-31(28(32)25-16-24(25)27-6-4-5-15-30-27)23-13-11-22(12-14-23)21-9-7-20(8-10-21)18-33-2/h4-15,19,24-26H,16-18,29H2,1-3H3/t19-,24-,25-,26-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Xanthan gum} web|{Xanthan gum} {Biochemical Assay Reagents}|{Xanthan gum} Technical Information|{Xanthan gum} Formula|{Xanthan gum} supplier|{Xanthan gum} Cancer} |Shelf Life: ≥12 months if stored properly.{{Secukinumab} MedChemExpress|{Secukinumab} Interleukin Related|{Secukinumab} Protocol|{Secukinumab} Data Sheet|{Secukinumab} custom synthesis|{Secukinumab} Epigenetic Reader Domain} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:25040798 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|RTI-13951-33 is a potent, selective, and brain-penetrant GPR88 agonist, with an EC50 of 25 nM in GPR88 cAMP functional assay. RTI-13951-33 elevates [35S]-GTPγS binding (EC50， 535 nM) in mouse striatal membranes but not in membranes from GPR88 KO mice. RTI-13951-33 has weak affinities at kappa opioid receptor (KOR; Ki, 2.29 μM), vesicular monoamine transporter (VMAT; Ki, 4.23 μM), and moderate affinity at serotonin transporter (SERT; Ki, 0.75 μM), however, RTI-13951-33 poorly inhibits SERT (IC50, 25.1 ± 2.7 μM).|In Vivo:|RTI-13951-33 (10 mg/kg, i.p.) has sufficient brain penetration, with t1/2 of 48 min and 87 min in rat plasma and brain. RTI-13951-33 (10 and 20 mg/kg, i.p.) dose-dependently decreases alcohol lever responses in a rat model of alcohol self-administration.|Products are for research use only. Not for human use.|