Product Name :
ML338
Description:
ML338 is a selective small molecule inhibitor probe of non-replicating Mycobacterium tuberculosis bacilli and is against the non-replicating M. tuberculosis with IC90 and IC99 values of 1 μM and 4 μM, respectively by CFU. ML338 is a invaluable tool for identifying both essential functions and vulnerabilities of the M. tuberculosis bacilli in the nutrient deprivation states. ML338 can be used for the study of M. tuberculosis chemotherapy.
CAS:
1630160-25-6
Molecular Weight:
369.83
Formula:
C17H12ClN5OS
Chemical Name:
2-(4-chlorophenyl)-5-{[(1-phenyl-1H-1,2,3-triazol-4-yl)methyl]sulfanyl}-1,3,4-oxadiazole
Smiles :
ClC1C=CC(=CC=1)C1=NN=C(O1)SCC1=CN(N=N1)C1C=CC=CC=1
InChiKey:
GMRWWIAYZWSOAZ-UHFFFAOYSA-N
InChi :
InChI=1S/C17H12ClN5OS/c18-13-8-6-12(7-9-13)16-20-21-17(24-16)25-11-14-10-23(22-19-14)15-4-2-1-3-5-15/h1-10H,11H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
ML338 is a selective small molecule inhibitor probe of non-replicating Mycobacterium tuberculosis bacilli and is against the non-replicating M. tuberculosis with IC90 and IC99 values of 1 μM and 4 μM, respectively by CFU. ML338 is a invaluable tool for identifying both essential functions and vulnerabilities of the M. tuberculosis bacilli in the nutrient deprivation states. ML338 can be used for the study of M. tuberculosis chemotherapy.|Product information|CAS Number: 1630160-25-6|Molecular Weight: 369.83|Formula: C17H12ClN5OS|Chemical Name: 2-(4-chlorophenyl)-5-{[(1-phenyl-1H-1,2,3-triazol-4-yl)methyl]sulfanyl}-1,3,4-oxadiazole|Smiles: ClC1C=CC(=CC=1)C1=NN=C(O1)SCC1=CN(N=N1)C1C=CC=CC=1|InChiKey: GMRWWIAYZWSOAZ-UHFFFAOYSA-N|InChi: InChI=1S/C17H12ClN5OS/c18-13-8-6-12(7-9-13)16-20-21-17(24-16)25-11-14-10-23(22-19-14)15-4-2-1-3-5-15/h1-10H,11H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{1-Deoxynojirimycin} medchemexpress|{1-Deoxynojirimycin} PI3K|{1-Deoxynojirimycin} Purity & Documentation|{1-Deoxynojirimycin} References|{1-Deoxynojirimycin} supplier|{1-Deoxynojirimycin} Epigenetics} |Shelf Life: ≥12 months if stored properly.{{Substance P} MedChemExpress|{Substance P} Metabolic Enzyme/Protease|{Substance P} Protocol|{Substance P} In Vivo|{Substance P} manufacturer|{Substance P} Epigenetic Reader Domain} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23546012 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ML338 (0-50 μM) has potency and selectivity against non-replicating M. tuberculosis with an IC90 of 1 μM. Additionally, ML338 have an IC99 against non-replicating M. tuberculosis (4 μM) which is excellent relative to current TB drugs. ML338 (0-50 μM; 48 hours) shows no toxicity to J774 macrophage cells up to 50 μM, the highest concentration. ML338 is against the non-replicating M. tuberculosis with IC90 and IC99 velues of 1 μM and 4 μM, respectively by CFU. Additionally, it against the replicating M. tuberculosis with IC90 and IC99 velues of 62 μM and 62 μM, respectively by CFU.|Products are for research use only. Not for human use.|