lf dose and started when vaginal HSP90 Inhibitor Formulation delivery immediately after 12, and following cesarean section soon after 8 hours, then therapeutic dose every single 24 hours till the finish of the 6th week soon after delivery. Recurrent VTEs and all bleedings were looked for and long-term efficacy in sufferers with deep venous thrombosis (DVT) was assessed by Villalta score and ultrasound investigation 52 months immediately after delivery. Results: We integrated 116 females. The outcomes recurrent VTEs, bleedings, and incidence of a post-thrombotic syndrome are shown in table 1. S. Strazisar; M. Kozak University Medical Centre Ljubljana, Health-related GSK-3 Inhibitor site Faculty of Ljubljana, Ljubljana, Slovenia PB1307|Outcomes of Remedy of Thromboembolic Disease throughout Pregnancy and Postpartum Single-center Practical experience Conclusions: The Quantra is usually a user-friendly cartridge-based coagulation monitoring program that swiftly provides a measure of a patient’s coagulation status which correlates well with conventional fibrinogen and platelet measurements. Figure two Effects of dilution and reconstitution on Quantra and traditional coagulation test parameters966 of|ABSTRACTTABLE 1 Outcomes in treated patientsRecurrent VTE on remedy DVT PE All Bleedings on remedy Minor through pregnancy Minor clinically essential in the course of pregnancy Key peripartum+ Significant postpartum All Postthrombotic syndrome in 95 individuals with DVTResults: The antepartum-course in both pregnancies was compliN ( ) 1 (0.9) 0 1 (0.9)cated by episodes of gastrointestinal-bleeding necessitating hospital admissions. For the duration of the initial delivery by caesarean section the blood loss was 600 ml . Having said that, it was difficult postoperatively by an infected pelvic haematoma which required laparotomy and drainage. The second delivery by elective caesarean section was complex by 1.5 litre post-partum haemorrhage. In both deliveries, intrapartum and post-partum haemorrhage was managed with blood item help requiring HLA matched platelets, red cell transfusions, recombinant VIIa and tranexamic acid. The two pregnancies resulted in delivery of two healthy female infants. Conclusions: Pregnancy, specially labour and delivery are difficult by a significantly enhanced danger in bleeding in Bernard Soulier Syndrome. Individualised treatment-plans and close liaison is expected in between obstetricians, haematologists, gynaecologists and blood transfusion service to manage these complicated pregnancies.6 (5.two) 3 (two.6) 1 (0.9) 1 (0.9) 11 (9.six) 6 (six.three)Gynecological lead to by a gynecologist, Villalta score 5.Conclusions: In our study the incidence of recurrent VTEs and bleedings was low. Only six women reported the improvement of the postthrombotic syndrome. We believe that our therapeutic regime is effective and secure.PB1309|Assessment with the Utility of your Pregnancy-adapted PB1308|Bernard Soulier Syndrome in Pregnancy: Management of Two Pregnancies in a Patient with Variant Bernard Soulier Syndrome A. Alexander1; E. Treharne1; E. jackson1; B. Myers2 B. Madan1; G. Gray2; S. Araujo1; D. Holloway1 1YEARS Algorithm in Predicting Presence of Pulmonary Embolism (PE) in Pregnant Women (PA-PE)The University of Leicester Medical College, Leicester, Uk; University Hospitals of Leicester, Leicester, United KingdomCentre for Haemostasis and Thrombosis, St Thomas‘ Hospital,London, United kingdom; 2Department of Women’s Well being, St Thomas’ Hospital, London, Uk Background: Bernard Soulier Syndrome is a rare inherited platelet disorder with primarily autosomal- recessive inheritance. The