D apoptosis, but not necrosis, in BxPC-3 cells (60 ) and MIA PaCa-2 (30 ) cells (PF-06454589 In stock Figure 3B,E). We also observed modifications within the expression of proteins involved in apoptosis: decreased expression of Bcl-xl and improved expression of cleaved caspase-3 in each cell lines (Figure 3C,F). In addition, the accumulation of LC3 proteins (Figure 3C,F) and autophagosomes detected via TEM in MIA PaCa-2 cells confirmed that autophagic flux was