Pancreatic necrosis and multiorgan failure. Diclophenac sodium together with indometacine is currently regular therapy in prevention of PEP although ceftazidime is feasible option treatment for sufferers with contraindication for nonsteroidal antiinflammatory drugs (NSAID). Aims Approaches: The main aim of this study was to figure out no matter if prophylactic,parenteraly administered ceftazidime reduces the frequency of PEP compared to rectally applied diclofenac sodium. All eligible individuals who underwent ERCP in tertiary care center for the duration of a month period (June to February have been enrolled in this study. Estimating the prevalence of PEP of and reduction of incidence of ( beta) calculated total sample size was . Inside a doubleblinded randomized controlled trial,patients a suppository containing a mg of diclofenac sodium rectally and placebo intravenously (group A) or g of ceftazidime intravenously and placebo rectally (group B) straight away prior to the process. PEP was diagnosed as outlined by the standardized criteria (Cotton criteria). The study was registered at Clinical Trial.gov (NCT) Outcomes: We included individuals,mean age of . years (SD),female There were sufferers in the diclofenac sodium group and within the ceftazidime group. The occurrence of postERCPPatients FCSEMS removability Total FCSEMS distal migration FCSEMS proximal migration MPD stricture resolution SEMS “induced” MPD stricture Asymptomatic A single patient excluded from followup (pancreatic cancer diagnosed months soon after stent removal). Conclusion: FCSEMS removability from the MPD in chronic pancreatitis was feasible in all instances. Just after year followup with the sufferers have been asymptomatic; this figure is comparable to these obtained with plastic stents. Occurrence of FCSEMS induced pancreatic strictures is usually a big challenge and deserves further assessment. Based on our practical experience the usage of FCSEMS within the MPD requires cautious evaluation in the setting of clinical trials.A Abstract quantity: P Biliary situation .Papillary stenosis,migrated CBD stones .Stones mm .Malignant extrahepatic strictures .Benign extrahepatic strictures .Biliary leaks .Stones mm .Hilar strictures . CI-IB-MECA manufacturer Lemmers Ulb Erasme,Brussels,Belgium,BSCI,Marborough,Usa Make contact with E mail Address: jacques.deviereerasme.ulb.ac.be Introduction: Many plastic stents are utilized for calibrating distal stricture in serious chronic pancreatitis. A single metal stent which doesn’t require exchanges could be helpful within this setting. Aims Procedures: Document feasibility and preliminary security in ongoing pancreatic endotherapy in individuals (pts) with painful chronic pancreatitis (CP) of Cremer Type IV making use of a new Nitinol “Soft” completely covered ( mm diameter) selfexpanding metal stent (Panc SEMS) (Pancreatic WallFlex,Boston Scientific Corporation,Marlborough,USA). Ten individuals enrolled. Intended Panc SEMS indwell mo in pts and mo in pts. Followup to mo ongoing. Interim final results reported on ITT basis. Results: pts (imply age , male). CP etiology alcoholic, hereditary, unknown. Calcific CP in PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/21688206 of pts. All pts had prior plastic stent placement(s) for the duration of a imply of yrs (variety mo to yrs). No pts had a prior Panc SEMS. At time of interim evaluation,all pts have been stent totally free with mean time on study d (variety d) and imply stentfree period of d (range d). In total stents have been placed,with pts having quick removal and replacement from the initial stent on account of deployment in unsatisfactory position and pts needing a second stent placement after prematu.