Product Name :
PPADS tetrasodium
Description:
PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC50s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC50~0.9 mM) and recombinant P2Y4 (IC50~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca²⁺exchanger in guinea pig airway smooth muscle.
CAS:
192575-19-2
Molecular Weight:
599.30
Formula:
C14H10N3Na4O12PS2
Chemical Name:
tetrasodium 4-2-[(2Z)-4-formyl-6-methyl-5-oxo-3-[(phosphonatooxy)methyl]-2,5-dihydropyridin-2-ylidene]hydrazin-1-ylbenzene-1,3-disulfonate
Smiles :
[Na+].Tusamitamab ravtansine web [Na+].[Na+].[Na+].CC1=N/C(=N\NC2=CC=C(C=C2S([O-])(=O)=O)S([O-])(=O)=O)/C(COP([O-])([O-])=O)=C(C=O)C1=O
InChiKey:
ZNPHTQDEBMCNDG-WCZAJHAHSA-J
InChi :
InChI=1S/C14H14N3O12PS2.4Na/c1-7-13(19)9(5-18)10(6-29-30(20,21)22)14(15-7)17-16-11-3-2-8(31(23,24)25)4-12(11)32(26,27)28;;;;/h2-5,16H,6H2,1H3,(H2,20,21,22)(H,23,24,25)(H,26,27,28);;;;/q;4*+1/p-4/b17-14-;;;;
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PPADS tetrasodiuma is a non-selective P2X receptor antagonist.Estetrol Data Sheet PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC50s ranging from 1 to 2.PMID:32658250 6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC50~0.9 mM) and recombinant P2Y4 (IC50~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca²⁺exchanger in guinea pig airway smooth muscle.|Product information|CAS Number: 192575-19-2|Molecular Weight: 599.30|Formula: C14H10N3Na4O12PS2|Chemical Name: tetrasodium 4-2-[(2Z)-4-formyl-6-methyl-5-oxo-3-[(phosphonatooxy)methyl]-2,5-dihydropyridin-2-ylidene]hydrazin-1-ylbenzene-1,3-disulfonate|Smiles: [Na+].[Na+].[Na+].[Na+].CC1=N/C(=N\NC2=CC=C(C=C2S([O-])(=O)=O)S([O-])(=O)=O)/C(COP([O-])([O-])=O)=C(C=O)C1=O|InChiKey: ZNPHTQDEBMCNDG-WCZAJHAHSA-J|InChi: InChI=1S/C14H14N3O12PS2.4Na/c1-7-13(19)9(5-18)10(6-29-30(20,21)22)14(15-7)17-16-11-3-2-8(31(23,24)25)4-12(11)32(26,27)28;;;;/h2-5,16H,6H2,1H3,(H2,20,21,22)(H,23,24,25)(H,26,27,28);;;;/q;4*+1/p-4/b17-14-;;;;|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: H2O : 50 mg/mL (83.43 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PPADS tetrasodiuma (1-30 μM; 10-50 minutes) inhibits Na+/Ca2+ exchanger reverse mode (NCXREV) in a time- and concentration dependent manner. PPADS tetrasodiuma is effective at other native and recombinant P2XRs. At human P2XRs sensitivity to PPADS tetrasodiuma depended on the subtype and was highest at the hP2X1, -2, -3, -5, and -7Rs with an IC50 of ∼1–3 and ∼30 μM for the hP2X4R.|In Vivo:|PPADS tetrasodiuma (15-60 mg/100g body weight (BW); i.p.; every 12 hours for 8 days) inhibits glomerular mesangial cells (MC) proliferation without altering proliferation of non-MC in vivo in mesangial proliferative glomerulonephritis.|Products are for research use only. Not for human use.|