Product Name :
GDC-0077
Description:
GDC-0077 (RG6114) is a potent selective inhibitor of PI3K alpha (PI3Kα) with an IC50 of 0.038 nM. GDC-0077 is >300-fold more selective for PI3K alpha over the other class I PI3K isoforms (beta, delta, and gamma) and >2000-fold more selective over PIK family members. GDC-0077 binds to the ATP binding site of PI3K and inhibits the phosphorylation of PIP2 to PIP3.
CAS:
2060571-02-8
Molecular Weight:
407.37
Formula:
C18H19F2N5O4
Chemical Name:
2-(4-[4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-9-oxa-3,6-diazatricyclo[8.Bedinvetmab custom synthesis 4.0.Dp44mT custom synthesis 0²,⁶]tetradeca-1(10),2,4,11,13-pentaen-12-ylamino)propanamide
Smiles :
CC(NC1=CC2OCCN3C=C(N=C3C=2C=C1)N1C(COC1=O)C(F)F)C(N)=O
InChiKey:
SGEUNORSOZVTOL-UHFFFAOYSA-N
InChi :
InChI=1S/C18H19F2N5O4/c1-9(16(21)26)22-10-2-3-11-13(6-10)28-5-4-24-7-14(23-17(11)24)25-12(15(19)20)8-29-18(25)27/h2-3,6-7,9,12,15,22H,4-5,8H2,1H3,(H2,21,26)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
GDC-0077 (RG6114) is a potent selective inhibitor of PI3K alpha (PI3Kα) with an IC50 of 0.038 nM. GDC-0077 is >300-fold more selective for PI3K alpha over the other class I PI3K isoforms (beta, delta, and gamma) and >2000-fold more selective over PIK family members. GDC-0077 binds to the ATP binding site of PI3K and inhibits the phosphorylation of PIP2 to PIP3.|Product information|CAS Number: 2060571-02-8|Molecular Weight: 407.37|Formula: C18H19F2N5O4|Chemical Name: 2-(4-[4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-9-oxa-3,6-diazatricyclo[8.4.0.0²,⁶]tetradeca-1(10),2,4,11,13-pentaen-12-ylamino)propanamide|Smiles: CC(NC1=CC2OCCN3C=C(N=C3C=2C=C1)N1C(COC1=O)C(F)F)C(N)=O|InChiKey: SGEUNORSOZVTOL-UHFFFAOYSA-N|InChi: InChI=1S/C18H19F2N5O4/c1-9(16(21)26)22-10-2-3-11-13(6-10)28-5-4-24-7-14(23-17(11)24)25-12(15(19)20)8-29-18(25)27/h2-3,6-7,9,12,15,22H,4-5,8H2,1H3,(H2,21,26)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Solubility (25°C).PMID:33241972 DMSO: 81 mg/mL(198.83 mM). Water: Insoluble.|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|