Product Name :
Isoxsuprine hydrochloride
Description:
Isoxsuprine hydrochloride is a beta-adrenergic receptor agonist with Kis of 13.65 μΜ and 3.48 μΜ for myometrial and placcntal beta-adrenergic receptor, respectively. Isoxsuprine hydrochloride is also a NMDA receptor antagonist.
CAS:
579-56-6
Molecular Weight:
337.84
Formula:
C18H24ClNO3
Chemical Name:
4-1-hydroxy-2-[(1-phenoxypropan-2-yl)amino]propylphenol; chlorohydrogen
Smiles :
Cl.CC(COC1C=CC=CC=1)NC(C)C(O)C1=CC=C(O)C=C1
InChiKey:
QVPSGVSNYPRFAS-UHFFFAOYSA-N
InChi :
InChI=1S/C18H23NO3.ClH/c1-13(12-22-17-6-4-3-5-7-17)19-14(2)18(21)15-8-10-16(20)11-9-15;/h3-11,13-14,18-21H,12H2,1-2H3;1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Isoxsuprine hydrochloride is a beta-adrenergic receptor agonist with Kis of 13.65 μΜ and 3.48 μΜ for myometrial and placcntal beta-adrenergic receptor, respectively. Isoxsuprine hydrochloride is also a NMDA receptor antagonist.|Product information|CAS Number: 579-56-6|Molecular Weight: 337.84|Formula: C18H24ClNO3|Chemical Name: 4-1-hydroxy-2-[(1-phenoxypropan-2-yl)amino]propylphenol; chlorohydrogen|Smiles: Cl.CC(COC1C=CC=CC=1)NC(C)C(O)C1=CC=C(O)C=C1|InChiKey: QVPSGVSNYPRFAS-UHFFFAOYSA-N|InChi: InChI=1S/C18H23NO3.ClH/c1-13(12-22-17-6-4-3-5-7-17)19-14(2)18(21)15-8-10-16(20)11-9-15;/h3-11,13-14,18-21H,12H2,1-2H3;1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 140 mg/mL (414.40 mM; Need ultrasonic). H2O : 15.56 mg/mL (46.06 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.SMPD1 Protein, Mouse (sf9, C-His) medchemexpress |Shelf Life: ≥12 months if stored properly.Anti-Mouse IL-1R Antibody Technical Information |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32512976 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Results show that Isoxsuprine hydrochloride inhibits circular chemorepellent induced defect (CCID) formation dose dependently (5 to 60 μM) and also inhibits 12(S)-HETE synthesis. Furthermore, Isoxsuprine hydrochloride is the only drug inhibiting the induction of all three mobility markers (MLC2, MYPT and paxillin).|In Vivo:|Total infarct volume in vehicle-treated animals is 279±25 mm3 compare to 137±18 mm3 in Isoxsuprine hydrochloride-treated animals.|References:|Falkay G, et al. Affinity of tocolytic agents on human placental and myometrial beta-adrenergic receptors. J Perinat Med. 1986;14(2):109-13.Kretschy N, et al. In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen. Br J Cancer. 2013 Feb 19;108(3):570-8.Hill JW, et al. Identification of isoxsuprine hydrochloride as a neuroprotectant in ischemic stroke through cell-based high-throughput screening. PLoS One. 2014 May 7;9(5):e96761.Products are for research use only. Not for human use.|