Product Name :
UNC0379 trifluoroacetate
Description:
UNC0379 trifluoroacetate salt is a substrate-competitive inhibitor of the lysine methyltransferase SETD8, the only known methyltransferase that catalyzes monomethylation of histone H4 lysine 20 (H4K20). HK420 methylation has been implicated in the regulation of a variety of biological processes including the DNA damage response. UNC0379 is selective for SETD8 over 15 other methyltransferases, with an IC50 value of 7.3 μM for SETD8 compared to IC50 vlaues over 100 μM for other methyltransferases.
CAS:
1620401-83-3
Molecular Weight:
527.58
Formula:
C25H36F3N5O4
Chemical Name:
6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-[5-(pyrrolidin-1-yl)pentyl]quinazolin-4-amine; trifluoroacetic acid
Smiles :
COC1=CC2=C(NCCCCCN3CCCC3)N=C(N=C2C=C1OC)N1CCCC1.OC(=O)C(F)(F)F
InChiKey:
NRGGPYZTHNAVFM-UHFFFAOYSA-N
InChi :
InChI=1S/C23H35N5O2.C2HF3O2/c1-29-20-16-18-19(17-21(20)30-2)25-23(28-14-8-9-15-28)26-22(18)24-10-4-3-5-11-27-12-6-7-13-27;3-2(4,5)1(6)7/h16-17H,3-15H2,1-2H3,(H,24,25,26);(H,6,7)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.CCCP Technical Information
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
UNC0379 trifluoroacetate salt is a substrate-competitive inhibitor of the lysine methyltransferase SETD8, the only known methyltransferase that catalyzes monomethylation of histone H4 lysine 20 (H4K20). HK420 methylation has been implicated in the regulation of a variety of biological processes including the DNA damage response.Xevinapant medchemexpress UNC0379 is selective for SETD8 over 15 other methyltransferases, with an IC50 value of 7.PMID:32542438 3 μM for SETD8 compared to IC50 vlaues over 100 μM for other methyltransferases.|Product information|CAS Number: 1620401-83-3|Molecular Weight: 527.58|Formula: C25H36F3N5O4|Synonym:|UNC-0379 trifluoroacetate|Chemical Name: 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-[5-(pyrrolidin-1-yl)pentyl]quinazolin-4-amine; trifluoroacetic acid|Smiles: COC1=CC2=C(NCCCCCN3CCCC3)N=C(N=C2C=C1OC)N1CCCC1.OC(=O)C(F)(F)F|InChiKey: NRGGPYZTHNAVFM-UHFFFAOYSA-N|InChi: InChI=1S/C23H35N5O2.C2HF3O2/c1-29-20-16-18-19(17-21(20)30-2)25-23(28-14-8-9-15-28)26-22(18)24-10-4-3-5-11-27-12-6-7-13-27;3-2(4,5)1(6)7/h16-17H,3-15H2,1-2H3,(H,24,25,26);(H,6,7)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|