Product Name :
MK-0608
Description:
MK-0608 is a potent and orally bioavailable inhibitor of HCV replication in vitro with an EC50 of 0.3 μM (EC90=1.3 μM) in the subgenomic-replicon assay.
CAS:
443642-29-3
Molecular Weight:
280.28
Formula:
C12H16N4O4
Chemical Name:
(2R,3R,4R,5R)-2-{4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-5-(hydroxymethyl)-3-methyloxolane-3,4-diol
Smiles :
C[C@]1(O)[C@@H](O[C@H](CO)[C@H]1O)N1C=CC2=C(N)N=CN=C12
InChiKey:
IRZRJANZDIOOIF-GAJNKVMBSA-N
InChi :
InChI=1S/C12H16N4O4/c1-12(19)8(18)7(4-17)20-11(12)16-3-2-6-9(13)14-5-15-10(6)16/h2-3,5,7-8,11,17-19H,4H2,1H3,(H2,13,14,15)/t7-,8-,11-,12-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{BS3 Crosslinker} site|{BS3 Crosslinker} Antibody-drug Conjugate/ADC Related|{BS3 Crosslinker} Activator|{BS3 Crosslinker} Biological Activity|{BS3 Crosslinker} In Vivo|{BS3 Crosslinker} custom synthesis}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
MK-0608 is a potent and orally bioavailable inhibitor of HCV replication in vitro with an EC50 of 0.3 μM (EC90=1.3 μM) in the subgenomic-replicon assay.|Product information|CAS Number: 443642-29-3|Molecular Weight: 280.{{Pomalidomide} MedChemExpress|{Pomalidomide} Ligands for E3 Ligase|{Pomalidomide} Biological Activity|{Pomalidomide} In Vivo|{Pomalidomide} manufacturer|{Pomalidomide} Autophagy} 28|Formula: C12H16N4O4|Chemical Name: (2R,3R,4R,5R)-2-{4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-5-(hydroxymethyl)-3-methyloxolane-3,4-diol|Smiles: C[C@]1(O)[C@@H](O[C@H](CO)[C@H]1O)N1C=CC2=C(N)N=CN=C12|InChiKey: IRZRJANZDIOOIF-GAJNKVMBSA-N|InChi: InChI=1S/C12H16N4O4/c1-12(19)8(18)7(4-17)20-11(12)16-3-2-6-9(13)14-5-15-10(6)16/h2-3,5,7-8,11,17-19H,4H2,1H3,(H2,13,14,15)/t7-,8-,11-,12-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 250 mg/mL (891.PMID:33334208 97 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Oral dosing of MK-0608 results in a potent antiviral effect. In preclinical pharmacokinetic experiments with rats, dogs, and rhesus monkeys, MK-0608 demonstrates good to excellent oral bioavailability (50 to 100%) and long plasma half-lives in dogs and rhesus macaques (9 and 14 h, respectively).|Products are for research use only. Not for human use.|