Product Name :
BIO-acetoxime

Description:
BIO-acetoxime (BIA) is a potent and selective GSK-3 inhibitor, with IC50s of both 10 nM for GSK-3α/β. BIO-acetoxime has anticonvulsant and anti-infection activity.

CAS:
667463-85-6

Molecular Weight:
398.21

Formula:
C18H12BrN3O3

Chemical Name:
[(Z, 3E)-6′-bromo-2′-oxo-1′, 2′-dihydro-1H, 3H-[2, 3′-biindolyliden]-3-ylidene]amino acetate

Smiles :
CC(=O)O/N=C1/C(/NC2=CC=CC=C/12)=C1\C2=CC=C(Br)C=C2NC\1=O

InChiKey:
MENDIXKFTXYTHJ-HPBPSMLHSA-N

InChi :
InChI=1S/C18H12BrN3O3/c1-9(23)25-22-16-12-4-2-3-5-13(12)20-17(16)15-11-7-6-10(19)8-14(11)21-18(15)24/h2-8,20H,1H3,(H,21,24)/b17-15-,22-16+

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
BIO-acetoxime (BIA) is a potent and selective GSK-3 inhibitor, with IC50s of both 10 nM for GSK-3α/β. BIO-acetoxime has anticonvulsant and anti-infection activity.|Product information|CAS Number: 667463-85-6|Molecular Weight: 398.21|Formula: C18H12BrN3O3|Synonym:|BIA|Chemical Name: [(Z, 3E)-6′-bromo-2′-oxo-1′, 2′-dihydro-1H, 3H-[2, 3′-biindolyliden]-3-ylidene]amino acetate|Smiles: CC(=O)O/N=C1/C(/NC2=CC=CC=C/12)=C1\C2=CC=C(Br)C=C2NC\1=O|InChiKey: MENDIXKFTXYTHJ-HPBPSMLHSA-N|InChi: InChI=1S/C18H12BrN3O3/c1-9(23)25-22-16-12-4-2-3-5-13(12)20-17(16)15-11-7-6-10(19)8-14(11)21-18(15)24/h2-8,20H,1H3,(H,21,24)/b17-15-,22-16+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 20.{{Lurasidone} web|{Lurasidone} Dopamine Receptor|{Lurasidone} Protocol|{Lurasidone} Description|{Lurasidone} custom synthesis|{Lurasidone} Epigenetic Reader Domain} 83 mg/mL (52.31 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|BIO-acetoxime (BIA; Compound 13) is a potent and selective GSK-3α/β inhibitor, with IC50s of both 10 nM.{{Flucytosine} site|{Flucytosine} Antibiotic|{Flucytosine} Biological Activity|{Flucytosine} Purity|{Flucytosine} manufacturer|{Flucytosine} Autophagy} BIO-acetoxime (BIA) shows weak effect on CDK5/p35 (IC50, 2.PMID:33085434 4 μM), CDK2/cyclin A (IC50, 4.3 μM), and CDK1/cyclin B (IC50, 63 μM). BIO-acetoxime (BIA) (5 μM and 10 μM) increases the viability of HSV-1-infected cells but shows little effect on morphology and viability of mockin-fected cells. Moreover, BIO-acetoxime (BIA) (0.625, 1.25, 2.5, 5, and 10 μM) significantly reduces the release of HSV-1 particles in OC3 cells, with an EC50 of 0.68 ± 0.28 μM. BIO-acetoxime (BIA) inhibits the expression of HSV-1 genes, and may not affect the nuclear targeting of HSV-1 capsids. In addition, delayed addition of BIO-acetoxime (BIA) also inhibits HSV-1 infection.|In Vivo:|BIO-acetoxime (BIA) shows anticonvulsant effects in the focal pilocarpine rat model at 0.5 mg/kg, and in 6-Hz fully kindled FVB/N mice at 0.5, 2.5, and 5 mg/kg via i.p. administration.|References:|Meijer L, et al. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol. 2003 Dec;10(12):1255-66.Hsu MJ, et al. Antiherpetic potential of 6-bromoindirubin-3′-acetoxime (BIO-acetoxime) in human oral epithelial cells. Arch Virol. 2013 Jun;158(6):1287-96.Aourz N, et al. Identification of GSK-3 as a Potential Therapeutic Entry Point for Epilepsy. ACS Chem Neurosci. 2018 Nov 6.Products are for research use only. Not for human use.|

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