Product Name :
R 80123
Description:
R 80123 is the Z-isomer of R 79595, is also a highly selective phosphodiesterase inhibitor. The fuction is similar to R 80122 (HY-100615, Revizinone).In vivo: The administration of Revizinone improved the haemodynamic profile with an increase in cardiac output, a decrease in systemic vascular resistance and a stable heart rate and mean arterial blood pressure. With regard to reconstitution of contractility and cardiac function Revizinone (E-isomer) is 10 fold more potent than R 79595 and nearly 100 fold more potent than R 80123 (Z-isomer). Revizinone significantly increases global LV function and systolic wall thickening in ischemic areas at doses greater than or equal to 0.16 mg/kg i.v.
CAS:
133718-30-6
Molecular Weight:
459.54
Formula:
C26H29N5O3
Chemical Name:
N-cyclohexyl-N-methyl-2-{[(Z)-({2-oxo-1H,2H,3H,5H-imidazo[2,1-b]quinazolin-7-yl}(phenyl)methylidene)amino]oxy}acetamide
Smiles :
CN(C1CCCCC1)C(=O)CO/N=C(/C1C=CC=CC=1)\C1=CC2CN3CC(=O)NC3=NC=2C=C1
InChiKey:
VHDUUXNHZLBGHQ-GNVQSUKOSA-N
InChi :
InChI=1S/C26H29N5O3/c1-30(21-10-6-3-7-11-21)24(33)17-34-29-25(18-8-4-2-5-9-18)19-12-13-22-20(14-19)15-31-16-23(32)28-26(31)27-22/h2,4-5,8-9,12-14,21H,3,6-7,10-11,15-17H2,1H3,(H,27,28,32)/b29-25-
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Fmoc-Asn(Trt)-OH} medchemexpress|{Fmoc-Asn(Trt)-OH} {Biochemical Assay Reagents}|{Fmoc-Asn(Trt)-OH} Protocol|{Fmoc-Asn(Trt)-OH} Description|{Fmoc-Asn(Trt)-OH} manufacturer|{Fmoc-Asn(Trt)-OH} Autophagy}
Shelf Life:
≥12 months if stored properly.{{Daptomycin} web|{Daptomycin} Anti-infection|{Daptomycin} Protocol|{Daptomycin} In Vitro|{Daptomycin} supplier|{Daptomycin} Epigenetic Reader Domain}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23381601
Additional information:
R 80123 is the Z-isomer of R 79595, is also a highly selective phosphodiesterase inhibitor. The fuction is similar to R 80122 (HY-100615, Revizinone).In vivo: The administration of Revizinone improved the haemodynamic profile with an increase in cardiac output, a decrease in systemic vascular resistance and a stable heart rate and mean arterial blood pressure. With regard to reconstitution of contractility and cardiac function Revizinone (E-isomer) is 10 fold more potent than R 79595 and nearly 100 fold more potent than R 80123 (Z-isomer). Revizinone significantly increases global LV function and systolic wall thickening in ischemic areas at doses greater than or equal to 0.16 mg/kg i.v.|Product information|CAS Number: 133718-30-6|Molecular Weight: 459.54|Formula: C26H29N5O3|Chemical Name: N-cyclohexyl-N-methyl-2-{[(Z)-({2-oxo-1H,2H,3H,5H-imidazo[2,1-b]quinazolin-7-yl}(phenyl)methylidene)amino]oxy}acetamide|Smiles: CN(C1CCCCC1)C(=O)CO/N=C(/C1C=CC=CC=1)\C1=CC2CN3CC(=O)NC3=NC=2C=C1|InChiKey: VHDUUXNHZLBGHQ-GNVQSUKOSA-N|InChi: InChI=1S/C26H29N5O3/c1-30(21-10-6-3-7-11-21)24(33)17-34-29-25(18-8-4-2-5-9-18)19-12-13-22-20(14-19)15-31-16-23(32)28-26(31)27-22/h2,4-5,8-9,12-14,21H,3,6-7,10-11,15-17H2,1H3,(H,27,28,32)/b29-25-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|