Product Name :
Fosaprepitant (dimeglumine)
Description:
Fosaprepitant, also known as MK0517, is an antiemetic drug, administered intravenously. It is a prodrug of aprepitant. Fosaprepitant was developed by Merck & Co. and was approved. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. Fosaprepitant is a weak inhibitor of CYP3A4, and aprepitant, the active moiety, is a substrate, inhibitor, and inducer of CYP3A4.
CAS:
265121-04-8
Molecular Weight:
809.62
Formula:
C30H39F7N5O11P
Chemical Name:
(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol; (3-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid
Smiles :
C[C@@H](O[C@H]1OCCN(CC2NC(=O)N(N=2)P(O)(O)=O)[C@H]1C1C=CC(F)=CC=1)C1C=C(C=C(C=1)C(F)(F)F)C(F)(F)F.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
InChiKey:
UGJUJYSRBQWCEK-GGXTVIBHSA-N
InChi :
InChI=1S/C23H22F7N4O6P.C7H17NO5/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)40-20-19(13-2-4-17(24)5-3-13)33(6-7-39-20)11-18-31-21(35)34(32-18)41(36,37)38;1-8-2-4(10)6(12)7(13)5(11)3-9/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H,31,32,35)(H2,36,37,38);4-13H,2-3H2,1H3/t12-,19+,20-;4-,5+,6+,7+/m10/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Rucaparib} web|{Rucaparib} Epigenetics|{Rucaparib} Purity & Documentation|{Rucaparib} References|{Rucaparib} supplier|{Rucaparib} Epigenetic Reader Domain}
Additional information:
Fosaprepitant, also known as MK0517, is an antiemetic drug, administered intravenously. It is a prodrug of aprepitant. Fosaprepitant was developed by Merck & Co. and was approved. It is a prodrug of Aprepitant.{{S-Adenosyl-L-methionine} medchemexpress|{S-Adenosyl-L-methionine} Apoptosis|{S-Adenosyl-L-methionine} Purity & Documentation|{S-Adenosyl-L-methionine} Data Sheet|{S-Adenosyl-L-methionine} custom synthesis|{S-Adenosyl-L-methionine} Autophagy} It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment.PMID:23833812 Fosaprepitant is a weak inhibitor of CYP3A4, and aprepitant, the active moiety, is a substrate, inhibitor, and inducer of CYP3A4.|Product information|CAS Number: 265121-04-8|Molecular Weight: 809.62|Formula: C30H39F7N5O11P|Synonym:|MK0517|MK 0517|MK-0517|Chemical Name: (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol; (3-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid|Smiles: C[C@@H](O[C@H]1OCCN(CC2NC(=O)N(N=2)P(O)(O)=O)[C@H]1C1C=CC(F)=CC=1)C1C=C(C=C(C=1)C(F)(F)F)C(F)(F)F.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO|InChiKey: UGJUJYSRBQWCEK-GGXTVIBHSA-N|InChi: InChI=1S/C23H22F7N4O6P.C7H17NO5/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)40-20-19(13-2-4-17(24)5-3-13)33(6-7-39-20)11-18-31-21(35)34(32-18)41(36,37)38;1-8-2-4(10)6(12)7(13)5(11)3-9/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H,31,32,35)(H2,36,37,38);4-13H,2-3H2,1H3/t12-,19+,20-;4-,5+,6+,7+/m10/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|