Product Name :
JNK Inhibitor VIII
Description:
JNK Inhibitor VIII (TCS JNK 6o) is an inhibitor of c-Jun N-terminal kinases with IC50 of 45 nM and 160 nM for JNK-1 and JNK-2, respectively. JNK Inhibitor VIII (TCS JNK 6o) inihibits JNK-1, JNK-2, and JNK-3 with Ki of 2 nM, 4 nM and 52 nM, respectively.
CAS:
894804-07-0
Molecular Weight:
356.38
Formula:
C18H20N4O4
Chemical Name:
N-(4-Amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxybenzeneacetamide
Smiles :
CCOC1=NC(=CC(N)=C1C#N)NC(=O)CC1=CC(=CC=C1OC)OC
InChiKey:
KQMPRSZTUSSXND-UHFFFAOYSA-N
InChi :
InChI=1S/C18H20N4O4/c1-4-26-18-13(10-19)14(20)9-16(22-18)21-17(23)8-11-7-12(24-2)5-6-15(11)25-3/h5-7,9H,4,8H2,1-3H3,(H3,20,21,22,23)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Caffeic acid phenethyl ester} web|{Caffeic acid phenethyl ester} Apoptosis|{Caffeic acid phenethyl ester} Biological Activity|{Caffeic acid phenethyl ester} Formula|{Caffeic acid phenethyl ester} custom synthesis|{Caffeic acid phenethyl ester} Epigenetic Reader Domain}
Additional information:
JNK Inhibitor VIII (TCS JNK 6o) is an inhibitor of c-Jun N-terminal kinases with IC50 of 45 nM and 160 nM for JNK-1 and JNK-2, respectively.{{Oteseconazole} site|{Oteseconazole} Cytochrome P450|{Oteseconazole} Protocol|{Oteseconazole} In Vitro|{Oteseconazole} custom synthesis|{Oteseconazole} Epigenetic Reader Domain} JNK Inhibitor VIII (TCS JNK 6o) inihibits JNK-1, JNK-2, and JNK-3 with Ki of 2 nM, 4 nM and 52 nM, respectively.|Product information|CAS Number: 894804-07-0|Molecular Weight: 356.38|Formula: C18H20N4O4|Synonym:|TCS JNK 6o|Chemical Name: N-(4-Amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxybenzeneacetamide|Smiles: CCOC1=NC(=CC(N)=C1C#N)NC(=O)CC1=CC(=CC=C1OC)OC|InChiKey: KQMPRSZTUSSXND-UHFFFAOYSA-N|InChi: InChI=1S/C18H20N4O4/c1-4-26-18-13(10-19)14(20)9-16(22-18)21-17(23)8-11-7-12(24-2)5-6-15(11)25-3/h5-7,9H,4,8H2,1-3H3,(H3,20,21,22,23)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO 71 mg/mL (199.23 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24103058 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|TCS-JNK-6a binds competitively and reversibly to the ATP site. This compound demonstrates a remarkable selectivity profile. Additionally, it shows some inhibition of c-Jun phosphorylation in hepG2 cells. TCS-JNK-6o is a 2, 5-dimethoxy analogue of TCS-JNK-6a with the dimethoxy substitution of the phenyl ring. TCS-JNK-6o shows further gains in potency.|In Vivo:|Pharmacokinetic profiles are determined for JNK Inhibitor VIII (TCS-JNK-6o) in Sprague-Dawley rats. JNK Inhibitor VIII (TCS-JNK-6o) showes a short half-life of roughly 1 h, with rapid clearance and barely measurable bioavailability. Microsomal incubation studies revealed that oxidative metabolism is very rapid with this compound.|References:|Bruce G Szczepankiewicz, et al. J Med Chem. 2006 Jun 15;49Products are for research use only. Not for human use.|