Product Name :
BMS-191095
Description:
BMS-191095 is an activators of mitochondrial ATP-sensitive potassium (mitoKATP) channels. Target: potassium channel in vitro: BMS-191095 induces mitochondrial-depolarization and vasodilation. BMS-191095 elicites a dose-dependent vasodilation in endothelium denuded cerebral arteries with 8.1 ± 2.3%, 31.6 ± 2.1%, and 39.5 ± 3.2% relaxation in response to 10, 50, and 100 μM, respectively. in vivo: In normal rats, BMS-191095-induced vasodilation was mediated by mitochondrial depolarization and calcium sparks generation in VSM and was reduced by inhibition of BKCa channels.
CAS:
166095-21-2
Molecular Weight:
408.88
Formula:
C22H21ClN4O2
Chemical Name:
(3R,4S)-4-[(4-chlorophenyl)[(1H-imidazol-2-yl)methyl]amino]-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-carbonitrile
Smiles :
CC1(C)OC2C=CC(=CC=2[C@@H]([C@H]1O)N(CC1NC=CN=1)C1=CC=C(Cl)C=C1)C#N
InChiKey:
SMIKIPXIDLITMP-LEWJYISDSA-N
InChi :
InChI=1S/C22H21ClN4O2/c1-22(2)21(28)20(17-11-14(12-24)3-8-18(17)29-22)27(13-19-25-9-10-26-19)16-6-4-15(23)5-7-16/h3-11,20-21,28H,13H2,1-2H3,(H,25,26)/t20-,21+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
BMS-191095 is an activators of mitochondrial ATP-sensitive potassium (mitoKATP) channels.{{Necitumumab} MedChemExpress|{Necitumumab} JAK/STAT Signaling|{Necitumumab} Technical Information|{Necitumumab} In Vitro|{Necitumumab} custom synthesis|{Necitumumab} Cancer} Target: potassium channel in vitro: BMS-191095 induces mitochondrial-depolarization and vasodilation.{{TMX1} MedChemExpress|{TMX1} Apoptosis|{TMX1} Protocol|{TMX1} In stock|{TMX1} custom synthesis|{TMX1} Epigenetic Reader Domain} BMS-191095 elicites a dose-dependent vasodilation in endothelium denuded cerebral arteries with 8.PMID:27102143 1 ± 2.3%, 31.6 ± 2.1%, and 39.5 ± 3.2% relaxation in response to 10, 50, and 100 μM, respectively. in vivo: In normal rats, BMS-191095-induced vasodilation was mediated by mitochondrial depolarization and calcium sparks generation in VSM and was reduced by inhibition of BKCa channels.|Product information|CAS Number: 166095-21-2|Molecular Weight: 408.88|Formula: C22H21ClN4O2|Chemical Name: (3R,4S)-4-[(4-chlorophenyl)[(1H-imidazol-2-yl)methyl]amino]-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-carbonitrile|Smiles: CC1(C)OC2C=CC(=CC=2[C@@H]([C@H]1O)N(CC1NC=CN=1)C1=CC=C(Cl)C=C1)C#N|InChiKey: SMIKIPXIDLITMP-LEWJYISDSA-N|InChi: InChI=1S/C22H21ClN4O2/c1-22(2)21(28)20(17-11-14(12-24)3-8-18(17)29-22)27(13-19-25-9-10-26-19)16-6-4-15(23)5-7-16/h3-11,20-21,28H,13H2,1-2H3,(H,25,26)/t20-,21+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (244.57 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Katakam PV, et al. Diversity of mitochondria-dependent dilator mechanisms in vascular smooth muscle of cerebral arteries from normal and insulin-resistant rats. Am J Physiol Heart Circ Physiol. 2014 Aug 15;307(4):H493-503.Products are for research use only. Not for human use.|