ression level of BRD7 review CSNK2A1 was linked to poor prognosis of OS for LIHC in TCGA dataset. Following this, we performed a retrospective clinical study on our own individuals to figure out no matter whether the expression level of CSNK2A1 could predict the prognosis of patients with LIHC. Survival evaluation on the 48 clinical LIHC individuals was performed. As shown in Figure 7E, LIHC sufferers with higher levels of protein expression of CSNK2A1 in tumor tissues had significantly shorter OS occasions compared to those withValidation of the CSNK2A1 Expression Levels in Clinical Tissue Samples from LIHC Patients of SYSUCC CohortIHC staining comparison of CSNK2A1 expression status in between tumor tissues and adjacent typical tissues from LIHC patients was performed to validate previous bioinformatic outcomes. In accordance with the results of IHC-P score of CSNK2A1 in tumor tissues from SYSUCC cohort, we could divide SYSUCC cohort (48 situations) into high CSNK2A1-doi.org/10.2147/IJGM.SInternational Journal of Common Medicine 2021:DovePressPowered by TCPDF (tcpdf.org)DovepressWu et alFigure five Correlation of CSNK2A1 expression with immune infiltration level in TCGA cancers. (A) Correlation of CSNK2A1 expression with infiltration degree of 22 kinds of immune cell subtypes in TCGA. Immune cells positively correlating with CSNK2A1 expression in TCGA database were labeled in red, even though immune cells negatively correlating with CSNK2A1 expression in TCGA database have been labeled in yellow. (B) Correlation of CSNK2A1 expression with immune infiltration level in BRCA, PRAD and UCEC. CSNK2A1 expression had important constructive correlation with resting CD4+ T memory cells and M1-macrophages, and important damaging correlation with CD8+ T cells, monocytes, FGFR4 Storage & Stability activated NK cells and plasma cells. P0.05; P0.01; P0.001. Abbreviations: CSNK2A1, casein kinase 2 alpha protein 1; TCGA, the cancer genome atlas; Neu, neutrophils; Eos, eosinophils; act-Mas, activated mast cells; res-Mas, resting mast cells; act-DC, activated dendritic cells; res-DC, resting dendritic cells; Mac-M2, macrophages M2; Mac-M1, macrophages M1; Mac-M0, macrophages M0; Mono, monocytes; act-NK, activated NK cells; res-NK, resting NK cells; -T, -T cells; Tregs, regulatory T cells; follic-Th, follicular T helper cells; act-CD4+T, activated CD4+ T memory cells; res-CD4+T, resting CD4+ T memory cells; naivCD4+T, naive CD4+ T cells; CD8+T, CD8+ T cells; memo-B, memory B cells; naivB, naive B cells; BRCA, breast invasive carcinoma; PRAD, prostate adenocarcinoma; UCEC, uterine corpus endometrial carcinoma.International Journal of Common Medicine 2021:doi.org/10.2147/IJGM.SDovePressPowered by TCPDF (tcpdf.org)Wu et alDovepressFigure 6 Correlations among CSNK2A1 expression and tumor immunotherapy biomarkers in TCGA cancers. (A) Correlation among CSNK2A1 expression and immune checkpoint marker sets. (B) Radar map of correlation amongst CSNK2A1 expression and TMB. (C) Radar map of correlation involving CSNK2A1 expression and MSI. P0.05; P0.01; P0.001. Abbreviations: CSNK2A1, casein kinase two alpha protein 1; TCGA, the cancer genome atlas; TMB, tumor mutational burden; MSI, microsatellite instability.low expression levels of CSNK2A1 (P = 0.017), which was constant with our previous bioinformatic outcomes in LIHC instances from TCGA dataset.PPI Network and Enrichment Analysis of CSNK2A1 in CancersNext, to discover the prospective roles that CSNK2A1 took part inside the carcinogensis of cancers, we applied GeneMANIA online tool to obtain a PPI network for CSNK