Nd [54]. Moreover, 5-azaC can also inhibit RNA methylation, E.K., R.T. and T.A.R.; validation, regulatory layer for chondrogenic differentiation [55]. As a result, it’s affordable to a further R.Z. and T.A.R.; formal evaluation, J.V., E.K., L.D. and T.A.R.; investigation, J.V., K.K., K.K. and T.A.R.; resources, R.Z., T.A.R. and C.M.; writing–original draft preparation, J.V., E.K., C.M., R.Z., consider that option when the impact of 5-azaC treatment is evaluated.Cells 2021, 10,18 ofSupplementary Supplies: The following are readily available online at https://www.mdpi.com/article/10 .3390/cells10102678/s1, Table S1: Sequences of primer pairs employed for the PCR array analyses, Table S2: Sequences of primer pairs used for the RT-qPCR reactions, Table S3: Sequences of primer pairs made use of for the qMSP analyses, Table S4: Sequence data with the three UTR regions of Dnmt3a, Ogt and Tet1 genes with insert flanking T7 promoters for antisense probe preparation, Figure S1: Photomicrograph of an E15 mouse embryo utilized for in situ hybridization as a adverse control (no specific RNA probe was used), Figure S2: Quantitative (relative optical density) values on the Dnmt3a-, Tet1- and Ogt-specific in situ hybridization photomicrographs. Author Contributions: Conceptualization, R.Z. and T.A.R.; methodology, J.V., E.K., R.T. and T.A.R.; validation, R.Z. and T.A.R.; formal analysis, J.V., E.K., L.D. and T.A.R.; investigation, J.V., E.K., K.K. and T.A.R.; resources, R.Z., T.A.R. and C.M.; writing–original draft preparation, J.V., E.K., C.M., R.Z., T.A.R.; writing–review and editing, J.V., R.Z., T.A.R., C.M.; visualization, J.V., E.K. and T.A.R.; supervision, R.Z., T.A.R.; project administration, R.Z.; funding acquisition, R.Z., C.M., T.A.R. All authors have read and agreed towards the published version on the manuscript. Funding: This operate was supported by the 2020/R/20/2502 Gedeon Richter Plc. grant awarded to J.V. The publication was supported by the EFOP-3.6.1-16-2016-00022 plus the EFOP-3.six.3-VEKOP-16-201700009 projects, the projects are co-financed by the European Union along with the European Social Fund. C.M. was supported by the Premium Postdoctoral RPR 73401 In stock Investigation Fellowship of the E v Lor d Study Network (ELKH), plus the Young Researcher Excellence Programme (grant quantity: FK-134304) with the National Study, Development and Innovation Workplace, Hungary. Project no. TKP2020-NKA04 has been implemented together with the assistance offered in the National Research, Improvement and Innovation Fund of Hungary, financed below the 2020-4.1.1-TKP2020 funding scheme. T.A.R. received funding in the National Analysis, Improvement and Innovation Fund, Hungary (grant quantity: K131588). Institutional Review Board Statement: The study was conducted based on the suggestions from the Declaration of Helsinki, and approved by the CP-31398 custom synthesis Animal Care and Protection Committee in the University of Debrecen (2/2018/DEM ). Informed Consent Statement: Not applicable. Information Availability Statement: The information presented in this study are out there on request from the corresponding author. Acknowledgments: The authors would like to thank Krisztina B in the Department of Anatomy, Histology and Embryology for their skillful and exceptional technical help. Conflicts of Interest: The authors declare that they have no competing interests. This paper was written by the authors inside the scope of their academic and investigation positions. None with the authors have any relationships that could possibly be construed as biased or inappropriate. The f.