S1P5/EDG-8 Antibody (1196A) [Alexa Fluor® 594] Summary

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

EDG8
Edg-8
EDG8S1P receptor Edg-8
Endothelial differentiation G-protein-coupled receptor 8
endothelial differentiation, sphingolipid G-protein-coupled receptor, 8
LPB4
S1P receptor 5
S1P5
S1PR5
sphingosine 1-phosphate receptor 5
sphingosine 1-phosphate receptor EDG8
Sphingosine 1-phosphate receptor Edg-8
sphingosine-1-phosphate receptor 5
SPPR-1
SPPR-2

S1P₅ (Sphingosine-1 Phosphate receptor 5), also known as EDG-8 (Endothelial Differentiation Gene 8), is a 43-45 kDa member of the EDG family, S1P-binding subfamily of GPCRs. Along with S1P₁ -S1P₄ (or EDG-1, EDG-5, EDG-3 and EDG-6, respectively), S1P₅ is known to bind S1P, a lipid synthesized by platelets, neutrophils, smooth muscle cells, mast cells and select fibroblasts. Mouse S1P₅ is a 400 amino acid (aa) 7-transmembrane glycoprotein that is expressed on brain endothelium, renal mesangial cells, Ly6C⁺ (in human CD14⁺CD16^–) monocytes, pre- and mature oligodendrocytes, and CD27^–CD116⁺ (mature) NK cells. S1P₅ appears to play a role in cell trafficking. On monocytes and NK cells, S1P₅ promotes cell migration out of the bone marrow, a phenomenon that may not be related to an S1P concentration gradient. S1P₅ also helps maintain the integrity of the blood-brain-barrier. On oligodendrocytes and precursors, S1P₅ appears to regulate cell survival and pseudopod extension. The extracellular segment of mouse S1P₅ shares 96% and 94% aa sequence identity with rat and human S1P₅ extracellular domains, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.