Tariquidar dihydrochloride

Product Name : Tariquidar dihydrochlorideDescription:Tariquidar dihydrochloride (XR9576 dihydrochloride) is a potent and specific inhibitor of P-glycoprotein (P-gp) with the high affinity (Kd=5.1 nM).CAS: 1992047-62-7Molecular Weight:719.65Formula: C38H40Cl2N4O6Chemical Name: N-phenyl}carbamoyl)-4,5-dimethoxyphenyl]quinoline-3-carboxamide dihydrochlorideSmiles :…

Gluconate sodium

Product Name : Gluconate sodiumDescription:Gluconate sodium (D-Gluconic acid sodium salt) is a corrosion and scale inhibitor of ordinary steel in simulated cooling water.CAS: 527-07-1Molecular Weight:218.14Formula: C6H11NaO7Chemical Name: sodium (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoateSmiles :…

11-Hydroxycanthin-6-one

Product Name : 11-Hydroxycanthin-6-oneDescription:11-Hydroxycanthin-6-one, a canthin-6-one alkaloid, is an antitumor agent which shows potent cytotoxic activity.CAS: 75969-83-4Molecular Weight:236.23Formula: C14H8N2O2Chemical Name: 1,6-diazatetracyclohexadeca-3,5(16),7,9,12,14-hexaene-2,11-dioneSmiles : O=C1C=CC2NC=CC3C=2N1C1=CC=CC(=O)C=31InChiKey: IZNXKZBIIFOWPU-UHFFFAOYSA-NInChi : InChI=1S/C14H8N2O2/c17-11-3-1-2-10-13(11)8-6-7-15-9-4-5-12(18)16(10)14(8)9/h1-7,15HPurity: ≥98% (or refer to…

Schisandrin C

Product Name : Schisandrin CDescription:Schizandrin C is a compound that exerts anti-neuroinflammatory effects by upregulating phase II detoxifying/antioxidant enzymes in microglia.CAS: 61301-33-5Molecular Weight:384.42Formula: C22H24O6Chemical Name: 3,22-dimethoxy-12,13-dimethyl-5,7,18,20-tetraoxapentacyclodocosa-1(22),2,4(8),9,15,17(21)-hexaeneSmiles : CC1CC2=CC3OCOC=3C(OC)=C2C2=C(OC)C3OCOC=3C=C2CC1CInChiKey: HTBWBWWADZJXID-UHFFFAOYSA-NInChi :…

WAY-600

Product Name : WAY-600Description:WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM.CAS: 1062159-35-6Molecular Weight:494.59Formula: C28H30N8OChemical Name: 4-(6-(1H-indol-5-yl)-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolopyrimidin-4-yl)morpholineSmiles : C(C1=CN=CC=C1)N1CCC(CC1)N1N=CC2C1=NC(=NC=2N1CCOCC1)C1C=C2C=CNC2=CC=1InChiKey: FPEIJQLXFHKLJV-UHFFFAOYSA-NInChi : InChI=1S/C28H30N8O/c1-2-20(17-29-8-1)19-34-10-6-23(7-11-34)36-28-24(18-31-36)27(35-12-14-37-15-13-35)32-26(33-28)22-3-4-25-21(16-22)5-9-30-25/h1-5,8-9,16-18,23,30H,6-7,10-15,19H2Purity: ≥98% (or…

Nuezhenide

Product Name : NuezhenideDescription:Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and wnt/β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide)…

Difloxacin-d3 hydrochloride

Product Name : Difloxacin-d3 hydrochlorideDescription:Difloxacin-d3 (hydrochloride) is the deuterium labeled Difloxacin (hydrochloride).CAS: 1173021-89-0Molecular Weight:438.87Formula: C21H20ClF2N3O3Chemical Name: Smiles : Cl.C()()N1CCN(CC1)C1=CC2=C(C=C1F)C(=O)C(=CN2C1C=CC(F)=CC=1)C(O)=OInChiKey: JFMGBGLSDVIOHL-NIIDSAIPSA-NInChi : InChI=1S/C21H19F2N3O3.ClH/c1-24-6-8-25(9-7-24)19-11-18-15(10-17(19)23)20(27)16(21(28)29)12-26(18)14-4-2-13(22)3-5-14;/h2-5,10-12H,6-9H2,1H3,(H,28,29);1H/i1D3;Purity: ≥98% (or refer to the Certificate of Analysis)Shipping…

Dihydrostreptomycin sulfate

Product Name : Dihydrostreptomycin sulfateDescription:Dihydrostreptomycin sulfate is an aminoglycoside antibiotic, used to treat bacterial diseases in cattle, pigs and sheep.CAS: 5490-27-7Molecular Weight:1461.42Formula: C42H88N14O36S3Chemical Name: bis(N''--6-{oxy}-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy}-2,4,5-trihydroxycyclohexyl]guanidine); tris(sulfuric acid)Smiles : C1O(O2(N=C(N)N)(O)(N=C(N)N)(O)2O)(O2O(CO)(O)(O)2NC)1(O)CO.C1O(O2(N=C(N)N)(O)(N=C(N)N)(O)2O)(O2O(CO)(O)(O)2NC)1(O)CO.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=OInChiKey: CZWJCQXZZJHHRH-YCRXJPFRSA-NInChi…

Boc-amido-PEG9-amine

Product Name : Boc-amido-PEG9-amineDescription:Boc-amido-PEG9-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.CAS: 890091-43-7Molecular Weight:556.69Formula: C25H52N2O11Chemical Name: tert-butyl N-(29-amino-3,6,9,12,15,18,21,24,27-nonaoxanonacosan-1-yl)carbamateSmiles : CC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNInChiKey: RTTGVFBQUXJWJG-UHFFFAOYSA-NInChi : InChI=1S/C25H52N2O11/c1-25(2,3)38-24(28)27-5-7-30-9-11-32-13-15-34-17-19-36-21-23-37-22-20-35-18-16-33-14-12-31-10-8-29-6-4-26/h4-23,26H2,1-3H3,(H,27,28)Purity: ≥98%…

Mal-PEG8-acid

Product Name : Mal-PEG8-acidDescription:Mal-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.CAS: 1818294-46-0Molecular Weight:521.56Formula: C23H39NO12Chemical Name: 1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acidSmiles : OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCN1C(=O)C=CC1=OInChiKey: KLZPPWOSICDUKQ-UHFFFAOYSA-NInChi : InChI=1S/C23H39NO12/c25-21-1-2-22(26)24(21)4-6-30-8-10-32-12-14-34-16-18-36-20-19-35-17-15-33-13-11-31-9-7-29-5-3-23(27)28/h1-2H,3-20H2,(H,27,28)Purity: ≥98% (or…

Acemetacin-d4

Product Name : Acemetacin-d4Description:Product informationCAS: 1196151-16-2Molecular Weight:419.85Formula: C21H18ClNO6Chemical Name: 2--5-methoxy-2-methyl-1H-indol-3-yl}acetyl)oxy]acetic acidSmiles : C1=C(Cl)C()=C()C(C(=O)N2C3=CC=C(C=C3C(CC(=O)OCC(O)=O)=C2C)OC)=C1InChiKey: FSQKKOOTNAMONP-LNFUJOGGSA-NInChi : InChI=1S/C21H18ClNO6/c1-12-16(10-20(26)29-11-19(24)25)17-9-15(28-2)7-8-18(17)23(12)21(27)13-3-5-14(22)6-4-13/h3-9H,10-11H2,1-2H3,(H,24,25)/i3D,4D,5D,6DPurity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as…

1-Triacontanol

Product Name : 1-TriacontanolDescription:1-Triacontanol is a naturally occurring plant growth regulator. 1-Triacontanol is a saturated long-chain alcohol that has growth-promoting activities on a number of plants.CAS: 593-50-0Molecular Weight:438.81Formula: C30H62OChemical Name:…

GSK2292767

Product Name : GSK2292767Description:GSK2292767 is a potent and selective PI3Kδ inhibitor.CAS: 1254036-66-2Molecular Weight:512.58Formula: C24H28N6O5SChemical Name: N--1,3-oxazol-2-yl}-1H-indazol-6-yl)-2-methoxypyridin-3-yl]methanesulfonamideSmiles : COC1N=CC(=CC=1NS(C)(=O)=O)C1=CC2NN=CC=2C(=C1)C1=NC=C(CN2CC(C)OC(C)C2)O1InChiKey: NLUPPCTVKHDVIQ-UHFFFAOYSA-NInChi : InChI=1S/C24H28N6O5S/c1-14-11-30(12-15(2)34-14)13-18-9-26-23(35-18)19-5-16(6-21-20(19)10-27-28-21)17-7-22(29-36(4,31)32)24(33-3)25-8-17/h5-10,14-15,29H,11-13H2,1-4H3,(H,27,28)Purity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition:…

Phytolaccagenin

Product Name : PhytolaccageninDescription:Phytolaccagenin, a triterpenoid saponin, is the active component of Radix Phytolaccae. Phytolcaccagenin has antifungal activity, anti-inflammatory activity and lower toxicityCAS: 1802-12-6Molecular Weight:532.71Formula: C31H48O7Chemical Name: (2S,4aR,6aS,6bR,8aR,9R,10R,11S,12aR,12bR,14bS)-8a,12b,14b-trihydrogenio-10,11-dihydroxy-9-(hydroxymethyl)-2-(methoxycarbonyl)-2,6a,6b,9,12a-pentamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acidSmiles :…

BMS-191095

Product Name : BMS-191095Description:BMS-191095 is an activators of mitochondrial ATP-sensitive potassium (mitoKATP) channels. Target: potassium channel in vitro: BMS-191095 induces mitochondrial-depolarization and vasodilation. BMS-191095 elicites a dose-dependent vasodilation in endothelium…

BAY-204

Product Name : BAY-204Description:BAY-204 is an inhibitor of Casein kinase 1 alpha and delta(CSNK1a and 5) useful for the treatment of proliferative disorders.CAS: 2468784-57-6Molecular Weight:533.54Formula: C29H26F3N5O2Chemical Name: Smiles : CN1CCC2NC(=C(NC3C=CC=CC=3)C=2C1=O)C1=CC(NC(=O)(CC(F)F)C2=CC=C(F)C=C2)=NC=C1InChiKey:…

Pirlindole

Product Name : PirlindoleDescription:Pirlindole is a selective and reversible MAO-A inhibitor. Pirlindole is also an inhibitor of enterovirus-D68 and coxsackievirus B3 (CV-B3).CAS: 60762-57-4Molecular Weight:226.32Formula: C15H18N2Chemical Name: Smiles : CC1=CC=C2C(=C1)C1CCCC3NCCN2C=13InChiKey: IWVRVEIKCBFZNF-UHFFFAOYSA-NInChi…

2-[(3-hydroxyadamantan-1-yl)amino]acetic acid

Product Name : 2-acetic acidDescription:Product informationCAS: 1032564-18-3Molecular Weight:225.28Formula: C12H19NO3Chemical Name: 3-Hydroxy-1-adamantyl-D-glycineSmiles : O12C3(C(C1)C(C2)C3)NCC(O)=OInChiKey: FSZTVAMKEHAGGP-RKBOTGTGSA-NInChi : InChI=1S/C12H19NO3/c14-10(15)6-13-11-2-8-1-9(3-11)5-12(16,4-8)7-11/h8-9,13,16H,1-7H2,(H,14,15)/t8-,9+,11+,12+Purity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as…

AM103

Product Name : AM103Description:AM 103 is a potent and selective FLAP inhibitor, with an IC50 value of 4.2 nM.CAS: 1147872-22-7Molecular Weight:632.77Formula: C36H39N3NaO4SChemical Name: 3-methyl}-5--1H-indol-2-yl]-2,2-dimethylpropanoic acid sodiumSmiles : .CC(C)(C)SC1C2=CC(=CC=C2N(CC2C=CC(=CC=2)C2=CN=C(C=C2)OC)C=1CC(C)(C)C(O)=O)OCC1=CC=CC=N1 |^1:0|InChiKey: VANSVYMYESBUFV-UHFFFAOYSA-NInChi…

Tetrazine-Ph-NHS ester

Product Name : Tetrazine-Ph-NHS esterDescription:Tetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.CAS: 1616668-55-3Molecular Weight:313.27Formula: C14H11N5O4Chemical Name: 2,5-dioxopyrrolidin-1-yl 2-acetateSmiles : O=C(CC1C=CC(=CC=1)C1N=NC=NN=1)ON1C(=O)CCC1=OInChiKey: ORWDYVDDJMYIQA-UHFFFAOYSA-NInChi :…

Tos-PEG2-CH2COOH

Product Name : Tos-PEG2-CH2COOHDescription:Tos-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.CAS: 1807537-35-4Molecular Weight:318.34Formula: C13H18O7SChemical Name: 2-(2-{2-ethoxy}ethoxy)acetic acidSmiles : CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOCC(O)=OInChiKey: QQHWSZBWDYTXGD-UHFFFAOYSA-NInChi : InChI=1S/C13H18O7S/c1-11-2-4-12(5-3-11)21(16,17)20-9-8-18-6-7-19-10-13(14)15/h2-5H,6-10H2,1H3,(H,14,15)Purity: ≥98%…

Azido-PEG8-NHBoc

Product Name : Azido-PEG8-NHBocDescription:Azido-PEG8-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.CAS: 2231845-12-6Molecular Weight:538.63Formula: C23H46N4O10Chemical Name: tert-butyl N-(26-azido-3,6,9,12,15,18,21,24-octaoxahexacosan-1-yl)carbamateSmiles : CC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCN==InChiKey: BDFYYRYBZUPGSL-UHFFFAOYSA-NInChi : InChI=1S/C23H46N4O10/c1-23(2,3)37-22(28)25-4-6-29-8-10-31-12-14-33-16-18-35-20-21-36-19-17-34-15-13-32-11-9-30-7-5-26-27-24/h4-21H2,1-3H3,(H,25,28)Purity: ≥98% (or…

Tectorigenin 7-O-Xylosyl Glucoside

Product Name : Tectorigenin 7-O-Xylosyl GlucosideDescription:Tectorigenin 7-O-Xylosyl Glucoside is a glycosidic isoflavone isolated from Pueraria thomsonii flower.CAS: 231288-19-0Molecular Weight:594.52Formula: C27H30O15Chemical Name: 5-hydroxy-3-(4-hydroxyphenyl)-6-methoxy-7-{oxy}methyl)oxan-2-yl]oxy}-4H-chromen-4-oneSmiles : COC1=C(C=C2OC=C(C(=O)C2=C1O)C1C=CC(O)=CC=1)O1O(CO2OC(O)(O)2O)(O)(O)1OInChiKey: MCYJIRFKDCXYCX-YUPZTAPUSA-NInChi : InChI=1S/C27H30O15/c1-37-25-15(6-14-17(21(25)33)18(30)12(7-38-14)10-2-4-11(28)5-3-10)41-27-24(36)22(34)20(32)16(42-27)9-40-26-23(35)19(31)13(29)8-39-26/h2-7,13,16,19-20,22-24,26-29,31-36H,8-9H2,1H3/t13-,16-,19+,20-,22+,23-,24-,26+,27-/m1/s1Purity: ≥98% (or refer…

Iriflophenone

Product Name : IriflophenoneDescription:Iriflophenone, isolated from Aquilaria sinensis, stimulates MCF-7 and T-47D human breast cancer cells proliferation.CAS: 52591-10-3Molecular Weight:246.22Formula: C13H10O5Chemical Name: 2-(4-hydroxybenzoyl)benzene-1,3,5-triolSmiles : OC1C=C(O)C=C(O)C=1C(=O)C1C=CC(O)=CC=1InChiKey: AOJWDTJDEGSHOA-UHFFFAOYSA-NInChi : InChI=1S/C13H10O5/c14-8-3-1-7(2-4-8)13(18)12-10(16)5-9(15)6-11(12)17/h1-6,14-17HPurity: ≥98% (or refer…

Astressin

Product Name : AstressinDescription:Astressin is a potent corticotropin releasing factor (CRF) antagonist.CAS: 170809-51-5Molecular Weight:3563.16Formula: C161H269N49O42Chemical Name: (4S)-4-{carbamoyl}-2-methylbutyl]carbamoyl}-3-carboxypropyl]carbamoyl}pentyl]carbamoyl}-3-methylbutyl]carbamoyl}pentyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-2-carbamoylethyl]carbamoyl}-3--6-methyl-2,5,8,12-tetraoxo-1,4,7,13-tetraazacyclooctadecan-9-yl]carbamoyl}-3-carbamoylpropyl]carbamoyl}ethyl]carbamoyl}-3-methylbutyl]carbamoyl}-3-carbamoylpropyl]carbamoyl}-3-carboxypropyl]carbamoyl}ethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}ethyl]carbamoyl}pentyl]carbamoyl}-3-carboxypropyl]carbamoyl}-3-methylbutyl]carbamoyl}-2-methylpropyl]carbamoyl}-4--3-(1H-imidazol-4-yl)propanamido]-4-methylpentanamido]-4-methylpentanamido]-5-carbamimidamidopentanamido]butanoic acidSmiles : C(CC)(NC(=O)(NC(=O)(CCC(O)=O)NC(=O)(CCCC)NC(=O)(CC(C)C)NC(=O)(CCCCN)NC(=O)(CCCNC(N)=N)NC(=O)(CC(N)=O)NC(=O)1CCCCNC(=O)CC(NC(=O)(CCC(N)=O)NC(=O)(C)NC(=O)(CC(C)C)NC(=O)(CCC(N)=O)NC(=O)(CCC(O)=O)NC(=O)(C)NC(=O)(CCCNC(N)=N)NC(=O)(C)NC(=O)(CCCC)NC(=O)(CCC(O)=O)NC(=O)(CC(C)C)NC(=O)(NC(=O)(CCC(O)=O)NC(=O)(CCCNC(N)=N)NC(=O)(CC(C)C)NC(=O)(CC(C)C)NC(=O)(CC2=CNC=N2)NC(=O)(N)CC2C=CC=CC=2)C(C)C)C(=O)N(C)C(=O)N(CC2=CNC=N2)C(=O)N1)(C)CC)C(N)=OInChiKey: HPYIIXJJVYSMCV-MGDXKYBTSA-NInChi : InChI=1S/C161H269N49O42/c1-23-27-41-96(189-145(239)107(52-59-123(217)218)199-152(246)114(71-84(13)14)207-157(251)126(85(15)16)208-147(241)108(53-60-124(219)220)197-140(234)102(47-38-66-179-161(172)173)193-151(245)112(69-82(9)10)204-153(247)113(70-83(11)12)205-155(249)116(74-94-77-175-79-181-94)201-134(228)95(163)72-92-39-30-29-31-40-92)135(229)182-88(19)130(224)186-100(45-36-64-177-159(168)169)136(230)183-89(20)131(225)188-106(51-58-122(215)216)144(238)195-104(49-56-119(165)212)146(240)202-110(67-80(5)6)149(243)185-90(21)132(226)187-103(48-55-118(164)211)143(237)196-105-50-57-121(214)176-63-35-33-44-99(192-154(248)115(73-93-76-174-78-180-93)200-133(227)91(22)184-137(105)231)142(236)206-117(75-120(166)213)156(250)194-101(46-37-65-178-160(170)171)139(233)190-98(43-32-34-62-162)141(235)203-111(68-81(7)8)150(244)191-97(42-28-24-2)138(232)198-109(54-61-125(221)222)148(242)210-128(87(18)26-4)158(252)209-127(129(167)223)86(17)25-3/h29-31,39-40,76-91,95-117,126-128H,23-28,32-38,41-75,162-163H2,1-22H3,(H2,164,211)(H2,165,212)(H2,166,213)(H2,167,223)(H,174,180)(H,175,181)(H,176,214)(H,182,229)(H,183,230)(H,184,231)(H,185,243)(H,186,224)(H,187,226)(H,188,225)(H,189,239)(H,190,233)(H,191,244)(H,192,248)(H,193,245)(H,194,250)(H,195,238)(H,196,237)(H,197,234)(H,198,232)(H,199,246)(H,200,227)(H,201,228)(H,202,240)(H,203,235)(H,204,247)(H,205,249)(H,206,236)(H,207,251)(H,208,241)(H,209,252)(H,210,242)(H,215,216)(H,217,218)(H,219,220)(H,221,222)(H4,168,169,177)(H4,170,171,178)(H4,172,173,179)/t86-,87-,88-,89-,90-,91-,95+,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,126-,127-,128-/m0/s1Purity: ≥98% (or refer to the Certificate of…

Cbz-NH-PEG3-CH2COOH

Product Name : Cbz-NH-PEG3-CH2COOHDescription:Cbz-NH-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.CAS: 462100-05-6Molecular Weight:341.36Formula: C16H23NO7Chemical Name: 2-{2-amino}ethoxy)ethoxy]ethoxy}acetic acidSmiles : OC(=O)COCCOCCOCCNC(=O)OCC1C=CC=CC=1InChiKey: DMBZCDPECWJRJR-UHFFFAOYSA-NInChi : InChI=1S/C16H23NO7/c18-15(19)13-23-11-10-22-9-8-21-7-6-17-16(20)24-12-14-4-2-1-3-5-14/h1-5H,6-13H2,(H,17,20)(H,18,19)Purity: ≥98%…

(±)-Lisofylline-d6

Product Name : (±)-Lisofylline-d6Description:Product informationCAS: 1185995-26-9Molecular Weight:286.36Formula: C13H20N4O3Chemical Name: 1-(5-hydroxyhexyl)-3,7-di(²H₃)methyl-2,3,6,7-tetrahydro-1H-purine-2,6-dioneSmiles : C()()N1C=NC2=C1C(=O)N(CCCCC(C)O)C(=O)N2C()()InChiKey: NSMXQKNUPPXBRG-XERRXZQWSA-NInChi : InChI=1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8-9,18H,4-7H2,1-3H3/i2D3,3D3Purity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as non-hazardous…

WAY 208466 dihydrochloride

Product Name : WAY 208466 dihydrochlorideDescription:Product informationCAS: 1207064-61-6Molecular Weight:420.33Formula: C17H20Cl2FN3O2SChemical Name: {2-pyridin-1-yl]ethyl}dimethylamine dihydrochlorideSmiles : Cl.Cl.CN(C)CCN1C=C(C2C=CC=NC1=2)S(=O)(=O)C1C=C(F)C=CC=1InChiKey: BAOHMLBVCLITHA-UHFFFAOYSA-NInChi : InChI=1S/C17H18FN3O2S.2ClH/c1-20(2)9-10-21-12-16(15-7-4-8-19-17(15)21)24(22,23)14-6-3-5-13(18)11-14;;/h3-8,11-12H,9-10H2,1-2H3;2*1HPurity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient…

NGD 94-1

Product Name : NGD 94-1Description:Product informationCAS: 178928-68-2Molecular Weight:320.39Formula: C18H20N6Chemical Name: 2-{4-piperazin-1-yl}pyrimidineSmiles : C(C1=CN=C(N1)C1C=CC=CC=1)N1CCN(CC1)C1N=CC=CN=1InChiKey: OTVQCHUIPJYASM-UHFFFAOYSA-NInChi : InChI=1S/C18H20N6/c1-2-5-15(6-3-1)17-21-13-16(22-17)14-23-9-11-24(12-10-23)18-19-7-4-8-20-18/h1-8,13H,9-12,14H2,(H,21,22)Purity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as…

Cystamine dihydrochloride

Product Name : Cystamine dihydrochlorideDescription:Product informationCAS: 56-17-7Molecular Weight:225.20Formula: C4H14Cl2N2S2Chemical Name: 2-ethan-1-amine dihydrochlorideSmiles : Cl.Cl.NCCSSCCNInChiKey: YUFRRMZSSPQMOS-UHFFFAOYSA-NInChi : InChI=1S/C4H12N2S2.2ClH/c5-1-3-7-8-4-2-6;;/h1-6H2;2*1HPurity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature…

4-Fluoro-7-nitrobenzofurazan

Product Name : 4-Fluoro-7-nitrobenzofurazanSynonym: IUPAC Name : 4-fluoro-7-nitro-2,1,3-benzoxadiazoleCAS NO.:29270-56-2Molecular Weight : Molecular formula: C6H2FN3O3Smiles: (=O)C1=CC=C(F)C2=NON=C12Description: 4-Chloro-7-nitrobenzofurazan (NBD-chloride) was used in the following studies, Synthesis of fluorescent phospholipid-derivative, NBD-didecanoylphosphatidylethanolamine, Synthesis of…

Enrofloxacin

Product Name : EnrofloxacinSynonym: IUPAC Name : 1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acidCAS NO.:93106-60-6Molecular Weight : Molecular formula: C19H22FN3O3Smiles: CCN1CCN(CC1)C1=C(F)C=C2C(=O)C(=CN(C3CC3)C2=C1)C(O)=ODescription: Enrofloxacin is a broad spectrum antibiotic bactericidal agent used in veterinary medicine to treat…

(7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate, 98%

Product Name : (7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate, 98%Synonym: IUPAC Name : hexafluoro-λ⁵-phosphanuide; tris(pyrrolidin-1-yl)({3H-triazolopyridin-3-yloxy})phosphaniumCAS NO.Umeclidinium bromide :156311-83-0Molecular Weight : Molecular formula: C17H27F6N7OP2Smiles: F(F)(F)(F)(F)F.Omaveloxolone C1CCN(C1)(ON1N=NC2=CC=CN=C12)(N1CCCC1)N1CCCC1Description: PMID:23551549 MedChemExpress (MCE) offers a wide range of high-quality…

Aloin

Product Name : AloinSynonym: IUPAC Name : (10R)-1,8-dihydroxy-3-(hydroxymethyl)-10--9,10-dihydroanthracen-9-oneCAS NO.:1415-73-2Molecular Weight : Molecular formula: C21H22O9Smiles: OC1O((O)(O)1O)1C2=CC=CC(O)=C2C(=O)C2=C(O)C=C(CO)C=C12Description: Aloe exudant, used as a stimulant-laxativeSelinexor Netupitant PMID:23626759 MedChemExpress (MCE) offers a wide range of…

N,O-Bis(trimethylsilyl)trifluoroacetamide, with 1% TMCS, packaged under Argon in resealable ChemSeal™ bottles

Product Name : N,O-Bis(trimethylsilyl)trifluoroacetamide, with 1% TMCS, packaged under Argon in resealable ChemSeal™ bottlesSynonym: IUPAC Name : trimethylsilyl 2,2,2-trifluoro-N-(trimethylsilyl)ethanimidateCAS NO.:25561-30-2Molecular Weight : Molecular formula: C8H18F3NOSi2Smiles: C(C)(C)OC(=N(C)(C)C)C(F)(F)FDescription: N,O-Bis(trimethylsilyl)trifluoroacetamide is used for…

Hemin (porcine), 97+%

Product Name : Hemin (porcine), 97+%Synonym: IUPAC Name : iron(3+) 4,20-bis(2-carboxyethyl)-9,14-diethenyl-5,10,15,19-tetramethyl-21,22,23,24-tetraazapentacyclotetracosa-1(20),2,4,6(24),7,9,11,13(22),14,16,18-undecaene-21,23-diideCAS NO.:16009-13-5Molecular Weight : Molecular formula: C34H32FeN4O4Smiles: .Sacituzumab govitecan CC1=C2C(C=C3N=C(C=C4C(=CC5=NC(=C2)C(C)=C5C=C)C(C)=C4C=C)C(C)=C3CCC(O)=O)=C1CCC(O)=ODescription: Hemin is used in cellular protection and control mechanism.Tegafur-Uracil It…

1-Docosanol, 98%

Product Name : 1-Docosanol, 98%Synonym: IUPAC Name : docosan-1-olCAS NO.:661-19-8Molecular Weight : Molecular formula: C22H46OSmiles: CCCCCCCCCCCCCCCCCCCCCCODescription: Crizotinib Bathophenanthroline PMID:23907051 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and…

Phenanthrene, 97%

Product Name : Phenanthrene, 97%Synonym: IUPAC Name : phenanthreneCAS NO.Donepezil Hydrochloride :85-01-8Molecular Weight : Molecular formula: C14H10Smiles: C1=CC=C2C(C=CC3=CC=CC=C23)=C1Description: Lanosterol PMID:23563799 MedChemExpress (MCE) offers a wide range of high-quality research chemicals…

Flavone, 99+%

Product Name : Flavone, 99+%Synonym: IUPAC Name : 2-phenyl-4H-chromen-4-oneCAS NO.Omaveloxolone :525-82-6Molecular Weight : Molecular formula: C15H10O2Smiles: O=C1C=C(OC2=CC=CC=C12)C1=CC=CC=C1Description: Colistin sulfate PMID:25269910 MedChemExpress (MCE) offers a wide range of high-quality research chemicals…

2-Phenoxypropylamine, 98%

Product Name : 2-Phenoxypropylamine, 98%Synonym: IUPAC Name : 2-phenoxypropan-1-amine hydrochlorideCAS NO.:6437-49-6Molecular Weight : Molecular formula: C9H14ClNOSmiles: Cl.Fexofenadine hydrochloride CC(CN)OC1=CC=CC=C1Description: 2-Phenoxypropylamine is used as pharmaceutical intermediate.Epoprostenol sodium PMID:30125989

4-Methylcatechol, 96%

Product Name : 4-Methylcatechol, 96%Synonym: IUPAC Name : 4-methylbenzene-1,2-diolCAS NO.Asiatic acid :452-86-8Molecular Weight : Molecular formula: C7H8O2Smiles: CC1=CC=C(O)C(O)=C1Description: 4-Methylcatechol is used to synthesize antimicrobial, antioxidant.Omaveloxolone It also acts as effective…

6-Maleimidohexanoic acid

Product Name : 6-Maleimidohexanoic acidSynonym: IUPAC Name : 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoic acidCAS NO.:55750-53-3Molecular Weight : Molecular formula: C10H13NO4Smiles: OC(=O)CCCCCN1C(=O)C=CC1=ODescription: 6-Maleimidohexanoic acid is used as a probe for introducing maleimides groups into biomolecules…

3-(2-Pyridyl)-5,6-diphenyl-1,2,4-triazine-p,p’-disulfonic acid, disodium salt hydrat

Product Name : 3-(2-Pyridyl)-5,6-diphenyl-1,2,4-triazine-p,p'-disulfonic acid, disodium salt hydratSynonym: IUPAC Name : disodium 4-benzene-1-sulfonateCAS NO.:1264198-47-1Molecular Weight : Molecular formula: C20H12N4Na2O6S2Smiles: .Galcuronokinase .GDNF Protein, Human S(=O)(=O)C1=CC=C(C=C1)C1=C(N=C(N=N1)C1=CC=CC=N1)C1=CC=C(C=C1)S()(=O)=ODescription: PMID:23833812

Ursolic acid, 95%

Product Name : Ursolic acid, 95%Synonym: IUPAC Name : (1S,2R,4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acidCAS NO.:77-52-1Molecular Weight : Molecular formula: C30H48O3Smiles: C1CC2(CC3(C)C(=CC45(C)CC(O)C(C)(C)5CC34C)21C)C(O)=ODescription: Trimethobenzamide hydrochloride Clopidogrel PMID:23543429

Owfrequencyoffamilialpituitarytumors, thesmallsizeofaffectedfamilies,andtheverylowprevalenceof mutationswithinthesefamilies,costlygeneticscreeningisnotyet convincinglywarranted.Accuraterelativelylow-costmeasurement ofserumIGF1levelsiscurrentlythemosteffectivescreeningfor affectedpatientswithGH-secretingpituitarytumors. Acromegaly

Owfrequencyoffamilialpituitarytumors, thesmallsizeofaffectedfamilies,andtheverylowprevalenceof mutationswithinthesefamilies,costlygeneticscreeningisnotyet convincinglywarranted.Accuraterelativelylow-costmeasurement ofserumIGF1levelsiscurrentlythemosteffectivescreeningfor affectedpatientswithGH-secretingpituitarytumors. Acromegaly remedy Severaltreatmentoptionsarecurrentlyavailableforacromegaly (Table2). Surgery ResectionofGH-secretingpituitaryadenomasistechnicallychallengingbecauseoftheanatomicinaccessibilityofthepituitary andbonysellarconfinesandtheproximityofvitalbrainandvascularstructures.Functioningtumormicrofociofteninvadedural spaces,arenotreadilyvisibleatsurgery,andcontinuetosecrete GHaftertumorresection.GH-secretingtumorshaveapropensitytoinvadelaterallyintothecavernoussinus,precludingsafe resection.Tumor-associatedinternalcarotidarterytortuosityand microaneurysmsalsorequiresurgicalcautionandalertness.Over 90 ofresectionsareperformedviaanendonasaltranssphenoidal strategy,oftenwithminimallyinvasiveendoscopictechniques. ComputerizedimageguidanceandintraoperativeMRIcoupled with improvement of microinstrumentation and optics have resultedinsafe,helpful,andminimallytraumaticprocedures whenperformedbyskilledandexperiencedneurosurgeons(S23).…

Hyl succinimidyl carbonate 1-O-Benzotriazole-N,N,N’,N’-tetramethyl-uromium-hexafluoro-phosphate Hydrochloric acid Histidine

Hyl succinimidyl carbonate 1-O-Benzotriazole-N,N,N',N'-tetramethyl-uromium-hexafluoro-phosphate Hydrochloric acid Histidine 1-Hydroxybenzotriazole High-performance liquid chromatography Higher resolution mass spectra Leucine Lithium hydroxide Methanol Magnesium sulfate Methyltrityl Mass-to-charge ratio Sodium bicarbonateNIH-PA Author Manuscript NIH-PA Author…

P_IGA_357344 Sc3_SNP_IGA_358948 0.0 2.9 4.three five.7 10.2 13.0 14.0 17.5 19.0 22.0 25.1 28.2 29.7 30.3 31.0 34.0 38.7 40.three 41.9 43.four 49.eight 52.9 57.four 57.8 58.4 59.2 60.six 67.0 70.LG3,4-Dimethylstyrene_EJ/AA1,3,8-p-Menthatriene_EJ

P_IGA_357344 Sc3_SNP_IGA_358948 0.0 two.9 4.three five.7 10.2 13.0 14.0 17.five 19.0 22.0 25.1 28.two 29.7 30.three 31.0 34.0 38.7 40.3 41.9 43.four 49.8 52.9 57.four 57.eight 58.4 59.two 60.six 67.0…

(n=49) 103.3sirtuininhibitor5.5 (n=33) 87.5sirtuininhibitor3.2 (n=63) five.25sirtuininhibitor.94 (n=52) ten.6sirtuininhibitor.9 (n=46) two.25sirtuininhibitor.9 (n

(n=49) 103.3sirtuininhibitor5.5 (n=33) 87.5sirtuininhibitor3.2 (n=63) 5.25sirtuininhibitor.94 (n=52) ten.6sirtuininhibitor.9 (n=46) 2.25sirtuininhibitor.9 (n=46) 191.3sirtuininhibitor5.8 (n=67) 55.9sirtuininhibitor1.two (n=64) 122.1sirtuininhibitor4.four (n=64) 129.1sirtuininhibitor7.4 (n=64) 167.2sirtuininhibitor8.0 (n=34) 0.94sirtuininhibitor.eight (n=34) two.47sirtuininhibitor.7 (n=34) 26.5sirtuininhibitor4.7 (n=34) 39.8sirtuininhibitor8.two (n=34) BSM-treated…

Sduringthemetabolicstudy.Hyperlipidemicsubjectsoftenhave delayedLDLapoB-100catabolism(seesupplementalTable S3).Wehavedocumentedalsothatfeedingresultsinmore directTRLapoB-100catabolismandlessconversionofTRL apoB-100toLDLapoB-

Sduringthemetabolicstudy.Hyperlipidemicsubjectsoftenhave delayedLDLapoB-100catabolism(seesupplementalTable S3).Wehavedocumentedalsothatfeedingresultsinmore directTRLapoB-100catabolismandlessconversionofTRL apoB-100toLDLapoB-100,aswellasdelayedLDLapoB-100 catabolism,comparedwiththefastingstate(29).In spite of thedifferences,ourfindingsareconsistentwiththesepreviousstudiesandsupporttheconceptthatapoBinsdLDLs iscatabolizedmoreslowlythanapoBinlbLDLs. Our data indicate that approximately 80 of lbLDL apoB-100isderivedfromTRLapoB-100,withtheremainderMetabolism and proteomics of LDL subfractionsTABLE three. ApolipoproteincompositionoflbLDLandsdLDLduringplaceboandtreatmentwithrosuvastatin40mg/dayPlacebo(totalproteinspectralintensity,logbase2) Proteins lbLDL sdLDL PbRosuvastatin(totalproteinspectralintensity,logbase2)…

IL-6R -Actin Forward primer ATGGAAGAGAC Transthyretin/TTR Protein Biological Activity CTTCAGCTAC GGAATCTTGGA GCGAGTTGT TGCAAAGCTATA GGTGGAGAGCIL-6R -Actin

IL-6R -Actin Forward primer ATGGAAGAGAC Transthyretin/TTR Protein Biological Activity CTTCAGCTAC GGAATCTTGGA GCGAGTTGT TGCAAAGCTATA GGTGGAGAGCIL-6R -Actin Forward primer ATGGAAGAGAC CTTCAGCTAC GGAATCTTGGA GCGAGTTGT TGCAAAGCTATA GGTGGAGAGC AGTTGCCTTCTT GGGACTGA TCATTCAGAGCC AGCTGCCCAT CAAGCCTTTCC TGACAGAGG CATCTGAACCG…

ESNP locationPCR amplification primer sequence (5' ?3') aGccatcGat aGtcGaaacG taGGcacGaat ttGcttGaa tccaaGcGta tGctcaaGaa GcacaataGc GaGatGGtca

ESNP locationPCR amplification primer sequence (5' ?3') aGccatcGat aGtcGaaacG taGGcacGaat ttGcttGaa tccaaGcGta tGctcaaGaa GcacaataGc GaGatGGtca taatcctGGcG atGaGatcc tttGccaaGc tcctccatac GaacctcGca tGGttGaGat aGGGcacttG GttccaGata GctcatcaGG cttttGGaaG GcacaaGcca cccactattt GctcatcaGG cttttGGaaG GcacaaGcca…